The renal organic cation transport system mediates the tubular secretion of cationic
compounds including drugs, toxins and endogenous metabolites into urine. It consists of a …

Abstract Kidney injury molecule-1 (KIM-1) is a type I membrane protein, comprising an
extracellular portion and a cytoplasmic portion, which is expressed at very low levels in the …

In chronic kidney disease (CKD), progressive nephron loss causes glomerular sclerosis, as
well as tubulointerstitial fibrosis and progressive tubular injury. In this study, we aimed to …

Chronic renal failure (CRF) is a major public health problem worldwide. Hydrogen sulfide
(H2S) plays important roles in renal physiological and pathophysiological processes …

The immunosuppressive drug rapamycin has helped to identify a large signaling network
around the target of rapamycin (TOR) protein that integrates information on nutrient …

The first compound that inhibited the mammalian target of rapamycin (mTOR), sirolimus
(rapamycin) was discovered in the 1970s as a soil bacterium metabolite collected on Easter …

Inhibitors of mammalian target of rapamycin (mTOR) have immunosuppressive and anti-
cancer effects, but their effects on the progression of kidney disease are not fully understood …

Introduction Despite significant advancements in immunosuppressive regimens and surgical
techniques, the prevalence of adverse events related to immunosuppression remains a …

Recent studies have revealed the impact of antibiotic-induced microbiome depletion (AIMD)
on host glucose homeostasis. The kidney has a critical role in systemic glucose …

Because of the difficulty in detecting segment-specific response in the kidney, we
investigated the molecular events underlying acute kidney injury in the proximal tubules of …