Class I histone deacetylases (HDACs) are closely associated with the development of a
diverse array of diseases, including cancer, neurodegenerative disorders, HIV, and …

In this Perspective, we have brought together available biological evidence on hydrazides
as histone deacetylase inhibitors (HDACis) and as a distinct type of Zn-binding group (ZBG) …

HDAC11 is a class IV histone deacylase with no crystal structure reported so far. The
catalytic domain of HDAC11 shares low sequence identity with other HDAC isoforms, which …

Epigenetics involves reversible modifications in gene expression without altering the genetic
code itself. Among these modifications, histone deacetylases (HDACs) play a key role by …

Analogues of hormonal vitamin D, 1, 25-dihydroxyvitamin D (1, 25D), signal through the
nuclear vitamin D receptor (VDR). They have potential in combination therapies with other …

Herein, we report the synthesis and anticancer properties of 21 new 1, 3, 4-thiadiazole-2-yl-
imino-thiazolidine-4-one containing binary heterocyclic molecules. Cytotoxicity of the …

Based on the synergistic effects of topoisomerase (Top) inhibitors and histone deacetylase
(HDAC) inhibitors in cancer therapy, a series of novel Top/HDAC dual inhibitors were …

Microtubules, one of the cytoskeletons in eukaryotic cells, maintain the proper operation of
several cellular functions. Additionally, they are regulated by the acetylation of HDAC6 and …

Tyrosine kinase inhibitors (TKIs) have markedly improved the overall survival rate of patients
with chronic myeloid leukemia (CML), enabling them to achieve a normal life expectancy …

Triple-negative breast cancer (TNBC) is an aggressive subtype lacking estrogen receptors,
progesterone receptors and lacks HER2 overexpression. This absence of critical molecular …