Efficient and targeted delivery of siRNA in vivo

MS Shim, YJ Kwon - The FEBS journal, 2010 - Wiley Online Library
RNA interference (RNAi) has been regarded as a revolutionary tool for manipulating target
biological processes as well as an emerging and promising therapeutic strategy. In contrast …

Multifunctional nanoparticles self‐assembled from small organic building blocks for biomedicine

P Xing, Y Zhao - Advanced Materials, 2016 - Wiley Online Library
Supramolecular self‐assembly shows significant potential to construct responsive materials.
By tailoring the structural parameters of organic building blocks, nanosystems can be …

[PDF][PDF] Fusogenic reactive oxygen species triggered charge‐reversal vector for effective gene delivery

X Liu, J Xiang, D Zhu, L Jiang, Z Zhou, J Tang… - Advanced …, 2016 - researchgate.net
DOI: 10.1002/adma. 201504288 a reactive oxygen species (ROS)-labile charge-reversal
polymer, poly [(2-acryloyl) ethyl (p-boronic acid benzyl) diethylammonium bromide](B …

Esterase‐activated charge‐reversal polymer for fibroblast‐exempt cancer gene therapy

N Qiu, X Liu, Y Zhong, Z Zhou, Y Piao… - Advanced …, 2016 - Wiley Online Library
(Figure 1a). Taking advantage of the high cytosolic esterase activity in HeLa cancer cells but
low level in fibroblasts, the ERP/DNA polyplexes taken up by cancer cells quickly dissociate …

CO2‐Responsive Polymeric Vesicles that Breathe

Q Yan, R Zhou, C Fu, H Zhang, Y Yin, J Yuan - Angewandte Chemie, 2011 - infona.pl
Vesikel atmen CO 2! Ein neuer Vesikeltyp, der sich aus Amidin‐haltigen
Diblockcopolymeren selbstorganisiert,„atmet “. Werden die Vesikel mit CO 2 oder Ar …

Self‐assembled fluorodendrimers combine the features of lipid and polymeric vectors in gene delivery

H Wang, Y Wang, Y Wang, J Hu, T Li, H Liu… - Angewandte …, 2015 - Wiley Online Library
An ideal vector in gene therapy should exhibit high serum stability, excellent
biocompatibility, a desired transfection efficacy and permeability into targeted tissues. Here …

An enzyme‐responsive polymeric superamphiphile

C Wang, Q Chen, Z Wang, X Zhang - Angewandte Chemie, 2010 - Wiley Online Library
Stimuli-responsive polymers have developed greatly in recent years as a result of their
prospective uses in biotechnology and drug-delivery systems.[1] Enzyme-responsive …

History of polymeric gene delivery systems

P Zhang, E Wagner - Polymeric Gene Delivery Systems, 2018 - Springer
As an option for genetic disease treatment and an alternative for traditional cancer
chemotherapy, gene therapy achieves significant attention. Nucleic acid delivery, however …

Photocontrolled self-assembly and disassembly of block ionomer complex vesicles: a facile approach toward supramolecular polymer nanocontainers

Y Wang, P Han, H Xu, Z Wang, X Zhang, AV Kabanov - Langmuir, 2010 - ACS Publications
A new concept of designing a photocontrollable supramolecular polymer nanocontainer
through the electrostatic association between an azobenzene-containing surfactant …

The highly efficient delivery of exogenous proteins into cells mediated by biodegradable chimaeric polymersomes

G Liu, S Ma, S Li, R Cheng, F Meng, H Liu, Z Zhong - Biomaterials, 2010 - Elsevier
Biodegradable chimaeric polymersomes based on asymmetric PEG-PCL-PDEA triblock
copolymers were prepared and investigated for delivery of exogenous proteins into cells …