There is a dramatic remodeling of the T cell compartment during aging. The most notorious
changes are the reduction of the naive T cell pool and the accumulation of memory-like T …

Neoantigens arising from mutations in tumor DNA provide targets for immune-based
therapy. Here, we report the clinical and immune data from a Phase Ib clinical trial of a …

Once regarded as an experimental artefact, cytotoxic CD4+ T cells (CD4 CTL) are presently
recognized as a biologically relevant T cell subset with important functions in anti-viral, anti …

Chimeric antigen receptors (CARs) repurpose natural signaling components to retarget T
cells to refractory cancers but have shown limited efficacy in persistent, recurrent …

Circulating T cells from peripheral blood (PBL) can provide a rich and noninvasive source
for antitumor T cells. By single-cell transcriptomic profiling of 36 neoantigen-specific T cell …

Palatine tonsils are secondary lymphoid organs (SLOs) representing the first line of
immunological defense against inhaled or ingested pathogens. We generated an atlas of …

Group A Streptococcus (GAS) infection is associated with multiple clinical sequelae,
including different subtypes of psoriasis. Such post-streptococcal disorders have been long …

B cells and T cells are key players in the defence against infections and malignancies. To
exert their function, B cells and T cells differentiate into effector and memory cells. Tight …

CD4+ T cells play an important role in immune responses against pathogens and cancer
cells. Although their main task is to provide help to other effector immune cells, a growing …

Decisively delineating cell identities from uni-and multimodal single-cell datasets is
complicated by diverse modalities, clustering methods, and reference atlases. We describe …