OD Howes, R McCutcheon, O Agid… - American Journal of …, 2017 - Am Psychiatric Assoc
Objective: Research and clinical translation in schizophrenia is limited by inconsistent definitions of treatment resistance and response. To address this issue, the authors …
Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …
M Knapp, G Wong - World Psychiatry, 2020 - Wiley Online Library
Economics and mental health are intertwined. Apart from the accumulating evidence of the huge economic impacts of mental ill‐health, and the growing recognition of the effects that …
SG Potkin, JM Kane, CU Correll, JP Lindenmayer… - NPJ …, 2020 - nature.com
Abstract Treatment-resistant schizophrenia (TRS), the persistence of positive symptoms despite≥ 2 trials of adequate dose and duration of antipsychotic medication with …
Abstract Treatment-resistant schizophrenia (TRS) will affect about one in three patients with schizophrenia. Clozapine is the only treatment approved for TRS, and patients should be …
The dopamine hypothesis is the longest standing pathoetiologic theory of schizophrenia. Because it was initially based on indirect evidence and findings in patients with established …
JM Kane, O Agid, ML Baldwin… - The Journal of …, 2019 - legacy.psychiatrist.com
Treatment-resistant schizophrenia (TRS) occurs in approximately 30% of individuals diagnosed with schizophrenia. The identification and management of TRS in clinical …
O Howes, R McCutcheon… - Journal of …, 2015 - journals.sagepub.com
The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of schizophrenia. Both were initially based on indirect evidence from pharmacological studies …
Antipsychotic drugs are the mainstay in the treatment of schizophrenia. However, one-third of patients do not show adequate improvement in positive symptoms with non-clozapine …