Background In two interim analyses of this trial, patients with advanced heart failure who
were treated with a fully magnetically levitated centrifugal-flow left ventricular assist device …

Extracorporeal membrane oxygenation (ECMO) is an increasingly acceptable life-saving
mechanical assistance system that provides cardiac and/or respiratory support for several …

Left ventricular assist device (LVAD) technology has improved the survival of advanced
heart failure patients. However, readmission rates following LVAD implantation remain high …

Purpose Device-induced blood damage contributes the hemolysis, thrombosis and bleeding
complications in patients supported with ventricular assist device (VAD). This study aims to …

The aim of this study was to examine the impact of the nonphysiological shear stress (NPSS)
on platelet hemostatic function relevant to thrombosis and bleeding in mechanically assisted …

This study was undertaken to develop a numerical/computational simulation of von
Willebrand Factor (vWF)-mediated platelet shear activation and deposition in an idealized …

Abstract von Willebrand Factor is a mechano-sensitive protein circulating in blood that
mediates platelet adhesion to subendothelial collagen and platelet aggregation at high …

Background Patients with continuous flow ventricular assist devices (CF‐VADs) are at high
risk for non‐surgical bleeding, speculated to associate with the loss of pulsatility following …

Background Continuous-flow left ventricular assist devices (LVADs) cause blood trauma that
includes von Willebrand factor degradation, platelet activation, and subclinical hemolysis …

Clot formation within membrane oxygenators (MOs) remains a critical problem during
extracorporeal membrane oxygenation (ECMO). The composition of the clots—in particular …