Sarcopenia is a systemic disease with progressive and generalized skeletal muscle
dysfunction defined by age-related low muscle mass, high content of muscle slow fibers, and …

Microglia are the resident immune cells of the central nervous system (CNS). It is well
established that microglia are activated and polarized to acquire different inflammatory …

Neurotransmitters are considered as a fundamental regulator in the process of neuronal
growth, differentiation and survival. Parkinson's Disease (PD) occurs due to extensive …

Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disorder,
caused by the degeneration of upper and lower motor neurons for which there is no truly …

The continuous adherence to the conventional “one target, one drug” paradigm has failed so
far to provide effective therapeutic solutions for heterogeneous and multifactorial diseases …

Amyotrophic lateral sclerosis (ALS) is a rare, devastating disease, causing movement
impairment, respiratory failure and ultimate death. A plethora of genetic, cellular and …

Over the years, researchers have leveraged a host of different in vivo models in order to
dissect amyotrophic lateral sclerosis (ALS), a neurodegenerative/neuroinflammatory …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that affects
selected cortical and spinal neuronal populations, leading to progressive paralysis and …

A relationship appears to exist between dysfunction of brain histamine (HA) and various
neuropsychiatric brain disorders. The possible involvement of brain HA in neuropathology …

Molecular and clinical heterogeneity is increasingly recognized as a common characteristic
of neurodegenerative diseases (NDs), such as Alzheimer's disease, Parkinson's disease …