Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
Adipose tissue as an endocrine organ
EE Kershaw, JS Flier - The Journal of Clinical Endocrinology & …, 2004 - academic.oup.com
Adipose tissue is a complex, essential, and highly active metabolic and endocrine organ.
Besides adipocytes, adipose tissue contains connective tissue matrix, nerve tissue …
Besides adipocytes, adipose tissue contains connective tissue matrix, nerve tissue …
Physiology of local renin-angiotensin systems
Since the first identification of renin by Tigerstedt and Bergmann in 1898, the renin-
angiotensin system (RAS) has been extensively studied. The current view of the system is …
angiotensin system (RAS) has been extensively studied. The current view of the system is …
White adipose tissue as endocrine organ and its role in obesity
BACKGROUND: Due to the public health problem represented by obesity, the study of
adipose tissue, particularly of the adipocyte, is central to the understanding of metabolic …
adipose tissue, particularly of the adipocyte, is central to the understanding of metabolic …
The renin angiotensin aldosterone system in obesity and hypertension: roles in the cardiorenal metabolic syndrome
PK Cabandugama, MJ Gardner… - Medical Clinics, 2017 - medical.theclinics.com
The seminal role of hypertension in the pathogenesis of the cardiorenal metabolic syndrome
(CRS) has significantly evolved over the past 5 years. The physiology of this is rooted in the …
(CRS) has significantly evolved over the past 5 years. The physiology of this is rooted in the …
Structure and functions of angiotensinogen
H Lu, LA Cassis, CW Vander Kooi… - Hypertension Research, 2016 - nature.com
Angiotensinogen (AGT) is the sole precursor of all angiotensin peptides. Although AGT is
generally considered as a passive substrate of the renin–angiotensin system, there is …
generally considered as a passive substrate of the renin–angiotensin system, there is …
The renin‐angiotensin system: a link between obesity, inflammation and insulin resistance
NS Kalupahana, N Moustaid‐Moussa - Obesity reviews, 2012 - Wiley Online Library
The renin‐angiotensin system (RAS) is classically known for its role in regulation of blood
pressure, fluid and electrolyte balance. Recently, several local RASs in organs such as …
pressure, fluid and electrolyte balance. Recently, several local RASs in organs such as …
Angiotensinogen suppression: a new tool to treat cardiovascular and renal disease
Multiple types of renin-angiotensin system (RAS) blockers exist, allowing interference with
the system at the level of renin, angiotensin-converting enzyme, or the angiotensin II …
the system at the level of renin, angiotensin-converting enzyme, or the angiotensin II …
The adipose-tissue renin–angiotensin–aldosterone system: role in the metabolic syndrome?
S Engeli, P Schling, K Gorzelniak, M Boschmann… - The international journal …, 2003 - Elsevier
Overfeeding of rodents leads to increased local formation of angiotensin II due to increased
secretion of angiotensinogen from adipocytes. Whereas angiotensin II promotes adipocyte …
secretion of angiotensinogen from adipocytes. Whereas angiotensin II promotes adipocyte …
Natriuretic peptides/cGMP/cGMP-dependent protein kinase cascades promote muscle mitochondrial biogenesis and prevent obesity
K Miyashita, H Itoh, H Tsujimoto, N Tamura… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE Natriuretic peptides (NPs) have been characterized as vascular hormones that
regulate vascular tone via guanylyl cyclase (GC), cyclic GMP (cGMP), and cGMP-dependent …
regulate vascular tone via guanylyl cyclase (GC), cyclic GMP (cGMP), and cGMP-dependent …