Matrix metalloproteinases (MMPs) play an important role in the degradation of extracellular
matrix components crucial for tumor growth, invasion and metastasis. MMPs are controlled …

Progressive matrix metalloproteinase (MMP)-induced degradation of the extracellular matrix
(ECM) of the articular cartilage is one of the major pathogenic osteoarthritis (OA) events …

Background The variance explained by genetic variants as identified in (genome-wide)
genetic association studies is typically small compared to family-based heritability estimates …

Background Colorectal cancer is a major global public health problem, with approximately
950 000 patients newly diagnosed each year. We report the first comprehensive field …

Abstract Background Matrix metalloproteases (MMPs) are proteolytic enzymes that
contribute to all stages of tumour progression, including the later stages of invasion and …

Background Extracellular matrix degradation by matrix metalloproteinases (MMPs) is an
important mechanism involved in tumor invasion and metastasis. Genetic variations of …

Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are
capable of cleaving all extra cellular matrix (ECM) substrates. Degradation of matrix is a key …

Background Colorectal cancer (CRC) remains one of the most common cancers worldwide.
We observed that MUC20 was significantly up-regulated in CRC patients with poor …

Abstract Matrix metalloproteinase (MMP) 2, MMP7 and MMP9 are important members of the
MMP family. Four polymorphisms in the promoter region of these MMPs, which are MMP2 …

The relationship between supplemental vitamins and various types of cancer has been the
focus of recent investigation, and supplemental vitamins have been reported to modulate …