Mechanisms of substrate processing during ER-associated protein degradation
JC Christianson, E Jarosch, T Sommer - Nature Reviews Molecular Cell …, 2023 - nature.com
Maintaining proteome integrity is essential for long-term viability of all organisms and is
overseen by intrinsic quality control mechanisms. The secretory pathway of eukaryotes …
overseen by intrinsic quality control mechanisms. The secretory pathway of eukaryotes …
Endoplasmic reticulum–associated protein degradation
L Krshnan, ML van de Weijer… - Cold Spring Harbor …, 2022 - cshperspectives.cshlp.org
Misfolded, potentially toxic proteins in the lumen and membrane of the endoplasmic
reticulum (ER) are eliminated by proteasomes in the cytosol through ER-associated …
reticulum (ER) are eliminated by proteasomes in the cytosol through ER-associated …
Order through destruction: how ER‐associated protein degradation contributes to organelle homeostasis
JC Christianson, P Carvalho - The EMBO journal, 2022 - embopress.org
The endoplasmic reticulum (ER) is a large, dynamic, and multifunctional organelle. ER
protein homeostasis is essential for the coordination of its diverse functions and depends on …
protein homeostasis is essential for the coordination of its diverse functions and depends on …
Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders
Recent studies using cell type–specific knockout mouse models have improved our
understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA …
understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA …
Maintenance of organellar protein homeostasis by ER-associated degradation and related mechanisms
MK Lemberg, K Strisovsky - Molecular Cell, 2021 - cell.com
Protein homeostasis mechanisms are fundamentally important to match cellular needs and
to counteract stress conditions. A fundamental challenge is to understand how defective …
to counteract stress conditions. A fundamental challenge is to understand how defective …
HBV genotype: a significant risk factor in determining which patients with chronic HBV infection should undergo surveillance for HCC: the hepatitis B Alaska study
BJ McMahon, LD Nolen, M Snowball, C Homan… - Hepatology, 2021 - journals.lww.com
Conclusions These data indicate that RNF5 inhibits NASH progression by targeting HRD1 in
the ubiquitin‐mediated proteasomal pathway. Targeting the RNF5–HRD1 axis may provide …
the ubiquitin‐mediated proteasomal pathway. Targeting the RNF5–HRD1 axis may provide …
Accumulated precursors of specific GPI-anchored proteins upregulate GPI biosynthesis with ARV1
We previously reported that glycosylphosphatidylinositol (GPI) biosynthesis is upregulated
when endoplasmic reticulum–associated degradation (ERAD) is defective; however, the …
when endoplasmic reticulum–associated degradation (ERAD) is defective; however, the …
Highly efficient expression and secretion of human lysozyme using multiple strategies in Pichia pastoris
Y Wang, B Wang, Y Gao, H Nakanishi… - Biotechnology …, 2023 - Wiley Online Library
Background Human lysozyme (hLYZ), an emerging antibacterial agent, has extensive
application in the food and pharmaceutical industries. However, the source of hLYZ is …
application in the food and pharmaceutical industries. However, the source of hLYZ is …
Hrd1 forms the retrotranslocation pore regulated by auto-ubiquitination and binding of misfolded proteins
V Vasic, N Denkert, CC Schmidt, D Riedel, A Stein… - Nature Cell …, 2020 - nature.com
During endoplasmic-reticulum-associated protein degradation (ERAD), misfolded proteins
are polyubiquitinated, extracted from the ER membrane and degraded by the proteasome …
are polyubiquitinated, extracted from the ER membrane and degraded by the proteasome …
The ERAD system is restricted by elevated ceramides
Misfolded proteins in the endoplasmic reticulum (ER) are removed through a process known
as ER-associated degradation (ERAD). ERAD occurs through an integral membrane protein …
as ER-associated degradation (ERAD). ERAD occurs through an integral membrane protein …