TNF is an inflammatory cytokine that upon binding to its receptor, TNFR1, can drive cytokine
production, cell survival, or cell death. TNFR1 stimulation causes activation of NF-κB, p38α …

Receptor interacting protein 1 (RIP1) kinase is a critical regulator of inflammation and cell
death signaling, and plays a crucial role in maintaining immune responses and proper …

The development of modern high-throughput instrumentation and improved core facility
infrastructures leads to an accumulation of large amounts of scientific data. However, for a …

Abstract Metadherin (AEG-1/MTDH/LYRIC) is a 582-amino acid transmembrane protein,
encoded by a gene located at chromosome 8q22, and distributed throughout the cytoplasm …

Mutations in mitochondrial acylglycerol kinase (AGK) cause Sengers syndrome, which is
characterized by cataracts, hypertrophic cardiomyopathy, and skeletal myopathy. AGK …

Adaptation of liver to the postprandial state requires coordinated regulation of protein
synthesis and folding aligned with changes in lipid metabolism. Here we demonstrate that …

Tumor necrosis factor (TNF) is one of the few cytokines successfully targeted by therapies
against inflammatory diseases. However, blocking this well studied and pleiotropic ligand …

Lead (Pb) is a kind of widespread toxic environmental pollutant which can cause harm to
organisms. Selenium (Se) has the property of mitigating Pb toxicity through decreasing …

Clinical and experimental evidence indicates that macrophages could promote solid-tumor
progression and metastasis. However, the mechanisms underlying this process remain …

Contact dermatitis and psoriasis are skin disorders caused by immune dysregulation, yet
much remains unknown about their underlying mechanisms. Ghrelin, a recently discovered …