Cutaneous leishmaniasis is a major public health problem and causes a range of diseases
from self-healing infections to chronic disfiguring disease. Currently, there is no vaccine for …

The complicated interactions between Leishmania and the host antigen-presenting cells
(APCs) have fundamental effects on the final outcome of the disease. Two major APCs …

Infection with the obligate intracellular protozoan Leishmania is thought to be initiated by
direct parasitization of macrophages, but the early events following transmission to the skin …

Parasites of the Leishmania genus are the causative agents of leishmaniasis in humans, a
disease that affects more than 12 million people worldwide. These parasites replicate …

Visceral Leishmaniasis (VL) is the most fatal form of disease leishmaniasis. To date, there
are no effective prophylactic measures and therapeutics available against VL. Recently, new …

Neutrophils and dendritic cells (DCs) converge at localized sites of acute inflammation in the
skin following pathogen deposition by the bites of arthropod vectors or by needle injection …

Advances in the understanding of leishmaniasis progression indicate that cellular
interactions more complex than the Th1/Th2 paradigm define the course of infection. Th17 …

Neutrophils are rapidly and massively recruited to sites of microbial infection, where they
can influence the recruitment of dendritic cells. Here, we have analyzed the role of …

The immunopathogenic competences of Leishmania (V.) braziliensis and L.(L.)
amazonensis were reviewed in the light of more recent features found in the clinical and …

Leishmania parasites have been widely used in experimental models to understand
generation, maintenance and failure of immune responses underlying resistance and …