The kidneys play a key role in maintaining total body homeostasis. The complexity of this
task is reflected in the unique architecture of the organ. Ureteral obstruction greatly affects …

This review attempts to show that there may be a relationship between inflammatory
processes induced by chronic overstimulation of the renin-angiotensin system (RAS) and …

Background In vivo models of uremia are important tools to study numerous aspects of acute
and chronic kidney disease. Mouse models are pivotal because most genetically …

Nitric oxide (NO) is synthesized by a family of NO synthases (NOS), including neuronal,
inducible, and endothelial NOS (n/i/eNOS). NO-mediated effects can be beneficial or …

Obstructive nephropathy is characterized by an inflammatory state in the kidney, that is
promoted by cytokines and growth factors produced by damaged tubular cells, infiltrated …

Ureteric obstruction is frequently encountered in primary care urology and can lead to
damage to the ipsilateral kidney. Relief of all types of obstruction generally leads to the …

Progression of chronic kidney disease remains a principal problem in clinical nephrology
and there is a pressing need for novel therapeutics and biomarkers. Aberrant promoter CpG …

Over recent years routine ultrasound scanning has identified increasing numbers of
neonates as having hydronephrosis and pelvi-ureteric junction obstruction (PUJO). This …

This study analyzes the role of angiotensin II (Ang II), via AT1 receptors, in the involvement
of cyclooxygenase (COX)-2-derived prostanoids in phenylephrine responses in …

Angiotensin II, a profibrotic cytokine, plays a main role in the initiation of renal fibrogenesis at
a very early stage leading to a progressive loss of renal function in unilateral ureteral …