Combined analyses of molecular data, such as DNA copy-number alteration, mRNA and
protein expression, point to biological functions and molecular pathways being deregulated …

Colorectal cancer (CRC) is a kind of solid tumor and the third most common cancer type in
the world. It is a heterogeneous disease characterized by genetic and epigenetic …

Cyclin E is frequently encoded by CCNE1 gene amplification in various malignancies. We
reviewed the medical records of patients with solid tumors displaying CCNE1 amplification …

In many human cancers p53 expression is lost or a mutant p53 protein is expressed. Over
the past 15 years it has become apparent that a large number of these mutant p53 proteins …

Background Ramucirumab plus erlotinib (RAM+ ERL) demonstrated superior progression-
free survival (PFS) in RELAY, a randomised Phase 3 trial in patients with untreated …

Lymphocytic infiltration is associated with better prognosis in several epithelial malignancies
including breast cancer. The tumor suppressor TP53 is mutated in approximately 30% of …

ABSTRACT TP53 mutation enhances vascular endothelial growth factor overexpression,
rendering cancer cells sensitive to pazopanib. Furthermore, treatment with vorinostat …

Breast cancer is a highly heterogeneous disease, and there are many forms of
categorization for breast cancer based on gene expression profiles. Gene expression …

Metaplastic carcinoma of the breast is a rare and heterogeneous subtype of breast
carcinoma with a generally poor outcome, and few therapeutic options once disease recurs …

We performed two phase I trials of the histone deacetylase inhibitor vorinostat combined
with either the vascular endothelial growth factor inhibitor pazopanib (NCT01339871) or the …