The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Background Plasma insulin levels are predominantly the product of the morphological mass
of insulin producing beta cells in the pancreatic islets of Langerhans and the functional …

Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

Diabetes is a major global problem. During the past decade, the genetic basis of various
monogenic forms of the disease, and their underlying molecular mechanisms, have been …

Over the past decades, hypomagnesemia (serum Mg2+< 0.7 mmol/L) has been strongly
associated with type 2 diabetes mellitus (T2DM). Patients with hypomagnesemia show a …

Pancreatic β cells secrete insulin, the body's only hormone capable of lowering plasma
glucose levels. Impaired or insufficient insulin secretion results in diabetes mellitus. The β …

Abstract Type 2 diabetes (T2DM) results when increases in beta cell function and/or mass
cannot compensate for rising insulin resistance. Numerous studies have documented the …

Dysfunctional microRNA (miRNA) networks contribute to inappropriate responses following
pathological stress and are the underlying cause of several disease conditions. In …

Statins are the gold-standard treatment for the prevention of primary and secondary
cardiovascular disease, which is the leading cause of mortality worldwide. Despite the safety …

ATP-sensitive potassium channels (KATP channels) link cell metabolism to electrical activity
by controlling the cell membrane potential. They participate in many physiological processes …