Phosphatase‐mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

MR Junttila, SP Li, J Westermarck - The FASEB Journal, 2008 - Wiley Online Library
Mitogen‐activated protein kinase (MAPK) pathways constitute a large modular network that
regulates a variety of physiological processes, such as cell growth, differentiation, and …

Nanoliposomes as the adjuvant delivery systems in cancer immunotherapy

P Zamani, AA Momtazi‐Borojeni, ME Nik… - Journal of cellular …, 2018 - Wiley Online Library
Cancer immunotherapy is one of the commonly used methods in the treatment of cancer.
The aim of this approach is to strengthen or restore immune function for effective diagnosis …

Mechanism of adjuvant activity of cationic liposome: phosphorylation of a MAP kinase, ERK and induction of chemokines

W Yan, W Chen, L Huang - Molecular immunology, 2007 - Elsevier
Cationic liposome has been effectively used as a delivery system for DNA and protein
vaccines. Recently, we discovered that strong anti-tumor immunity could be generated when …

Inhibition of the MAP kinase ERK protects from lipopolysaccharide-induced lung injury

K Schuh, A Pahl - Biochemical pharmacology, 2009 - Elsevier
The pathogenesis of chronic obstructive pulmonary disease (COPD) is characterized by
pulmonary inflammation associated with lung neutrophilia and elevated levels of pro …

Bone morphogenetic protein 7 promotes resistance to immunotherapy

MA Cortez, F Masrorpour, C Ivan, J Zhang… - Nature …, 2020 - nature.com
Immunotherapies revolutionized cancer treatment by harnessing the immune system to
target cancer cells. However, most patients are resistant to immunotherapies and the …

Novel hematopoietic progenitor kinase 1 inhibitor KHK-6 enhances T-cell activation

MJ Ahn, EH Kim, Y Choi, CH Chae, P Kim, SH Kim - PLoS One, 2024 - journals.plos.org
Inhibiting the functional role of negative regulators in immune cells is an effective approach
for developing immunotherapies. The serine/threonine kinase hematopoietic progenitor …

Stimulation of an immune response by cationic lipids

W Chen, W Yan, K Toney, G Conn… - US Patent …, 2014 - Google Patents
US8877206B2 - Stimulation of an immune response by cationic lipids - Google Patents
US8877206B2 - Stimulation of an immune response by cationic lipids - Google Patents …

TGF-β inhibits IL-2 production and promotes cell cycle arrest in TCR-activated effector/memory T cells in the presence of sustained TCR signal transduction

L Das, AD Levine - The Journal of Immunology, 2008 - journals.aai.org
TGF-β signaling is critical for controlling naive T cell homeostasis and differentiation;
however, the biological and biochemical changes induced by TGF-β in effector/memory T …

[HTML][HTML] Angiotensin II–induced MMP-2 activity and MMP-14 and basigin protein expression are mediated via the angiotensin II receptor type 1–mitogen-activated …

M Pons, SW Cousins, O Alcazar, GE Striker… - The American journal of …, 2011 - Elsevier
Accumulation of various lipid-rich extracellular matrix (ECM) deposits under the retinal
pigment epithelium (RPE) has been observed in eyes with age-related macular …

Directing t-cell immune responses for cancer vaccination and immunotherapy

PL Smith, K Piadel, AG Dalgleish - Vaccines, 2021 - mdpi.com
Cancer vaccination and immunotherapy revolutionised the treatment of cancer, a result of
decades of research into the immune system in health and disease. However, despite recent …