Mammalian copper homeostasis: Physiological roles and molecular mechanisms

S Lutsenko, S Roy, P Tsvetkov - Physiological reviews, 2025 - journals.physiology.org
In the past decade, evidence for the numerous roles of copper (Cu) in mammalian
physiology has grown exponentially. The discoveries of Cu involvement in cell signaling …

Current and potential therapies targeting inflammation in NASH

S Albhaisi, M Noureddin - Frontiers in endocrinology, 2021 - frontiersin.org
Nonalcoholic steatohepatitis (NASH) is the advanced form of nonalcoholic fatty liver disease
(NAFLD). It is characterized by hepatic steatosis, inflammation, hepatocellular injury, and …

Best practices and progress in precision-cut liver slice cultures

L Dewyse, H Reynaert, LA van Grunsven - International journal of …, 2021 - mdpi.com
Thirty-five years ago, precision-cut liver slices (PCLS) were described as a promising tool
and were expected to become the standard in vitro model to study liver disease as they tick …

Pathogenesis and therapeutic strategies related to non-alcoholic fatty liver disease

T Teng, S Qiu, Y Zhao, S Zhao, D Sun, L Hou… - International Journal of …, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD), one of the most common types of chronic liver
disease, is strongly correlated with obesity, insulin resistance, metabolic syndrome, and …

Inflammation and fibrogenesis in MAFLD: role of the hepatic immune system

P Torre, BM Motta, R Sciorio, M Masarone… - Frontiers in …, 2021 - frontiersin.org
Metabolic (dysfunction)-associated fatty liver disease (MAFLD) is the definition recently
proposed to better circumscribe the spectrum of conditions long known as non-alcoholic fatty …

Vascular adhesion Protein-1 (VAP-1)/Semicarbazide-sensitive amine oxidase (SSAO): a potential therapeutic target for atherosclerotic cardiovascular diseases

H Li, S Du, P Niu, X Gu, J Wang, Y Zhao - Frontiers in pharmacology, 2021 - frontiersin.org
Vascular adhesion protein-1 (VAP-1) is a semicarbazide-sensitive amine oxidase (SSAO),
whose enzymatic activity regulates the adhesion/exudation of leukocytes in/from blood …

Metabolic Dysfunction-Associated Steatotic Liver Disease in a Dish: Human Precision-Cut Liver Slices as a Platform for Drug Screening and Interventions

M Li, FT Larsen, MC van den Heuvel, K Gier, AR Gorter… - Nutrients, 2024 - mdpi.com
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing healthcare
problem with limited therapeutic options. Progress in this field depends on the availability of …

[HTML][HTML] Ex Vivo Tools and Models in MASLD Research

RI Velliou, E Giannousi, C Ralliou, E Kassi… - Cells, 2024 - pmc.ncbi.nlm.nih.gov
Metabolic dysfunction-associated fatty liver disease (MASLD) presents a growing global
health challenge with limited therapeutic choices. This review delves into the array of ex vivo …

Redefining the Role of Ornithine Aspartate and Vitamin E in Metabolic-Dysfunction-Associated Steatotic Liver Disease through Its Biochemical Properties

L Longo, RA Marschner, LBR de Freitas… - International Journal of …, 2024 - mdpi.com
It is known that the inflammation process leading to oxidative stress and thyroid hormone
metabolism dysfunction is highly altered in metabolic dysfunction associated with steatotic …

The role of vascular adhesion protein‐1 in diabetes and diabetic complications

IW Yen, HY Li - Journal of Diabetes Investigation, 2024 - Wiley Online Library
ABSTRACT Vascular adhesion protein‐1 (VAP‐1) plays a dual role with its adhesive and
enzymatic properties, facilitating leukocyte migration to sites of inflammation and catalyzing …