Heme is an essential molecule expressed ubiquitously all through our tissues. Heme plays
major functions in cellular physiology and metabolism as the prosthetic group of diverse …

Damage associated molecular patterns (DAMPs) are endogenous molecules originate from
damaged cells and tissues with the ability to trigger and/or modify innate immune responses …

The increase of extracellular heme is a hallmark of hemolysis or extensive cell damage.
Heme has prooxidant, cytotoxic, and inflammatory effects, playing a central role in the …

Objective To analyze the gut microbiota of patients with rheumatoid arthritis (RA) according
to disease activity. Methods An observational cross-sectional study of 110 patients with RA …

Hemolytic diseases include a variety of conditions with diverse etiologies in which red blood
cells are destroyed and large amounts of hemeproteins are released. Heme has been …

Transfusion‐associated necrotising enterocolitis (TANEC) is a life‐threatening disease with
a poor prognosis in preterm infants. This study explored whether and how heme induces …

Several large epidemiological and animal studies demonstrate a direct correlation between
dietary heme iron intake and/or systemic iron levels and cancer risk in several cancers …

Hemolysis causes an increase of intravascular heme, oxidative damage, and inflammation
in which macrophages play a critical role. In these cells, heme can act as a prototypical …

We previously reported that mice deficient in two Se-dependent glutathione peroxidases,
GPx1 and GPx2, have spontaneous ileocolitis. Disease severity depends on mouse genetic …

Integrins are transmembrane heterodimeric glycoproteins, present in most cell types that act
as mechanoreceptors, connecting extracellular matrix proteins to the cytoskeleton of the cell …