Cellular senescence, a major tumor-suppressive cell fate, has emerged from humble
beginnings as an in vitro phenomenon into recognition as a fundamental mechanism of …

Vascular aging is a key process determining health status of aged population. Aging is an
independent cardiovascular risk factor associated to an impairment of endothelial function …

Vascular endothelial dysfunction is regarded as a primary phenotypic expression of normal
human aging. This senescence-induced disorder is the likely culprit underlying the …

Background A reduction in number and function of endothelial progenitor cells (EPCs)
occurs in both physiologic aging and chronic heart failure (CHF). We assessed whether …

Aging is the main risk factor contributing to vascular dysfunction and the progression of
vascular diseases. In this review, we discuss the causes and mechanisms of vascular aging …

Reduced tissue levels of endothelial progenitor cells (EPCs) and functional impairment of
endothelium are frequently observed in patients with diabetes and cardiovascular disease …

Age is a significant risk factor for the development of vascular diseases, such as
atherosclerosis. Although pharmacological treatments, including statins and anti …

Aging is marked by changes that affect organs and resident stem cell function. Shorting of
telomeres, DNA damage, oxidative stress, deregulation of genes and proteins, impaired cell …

For more than a decade, endothelial progenitor cells (EPCs) have been implicated in
cardiovascular homeostasis. EPCs are believed to reside within the bone marrow in close …

Arterial remodeling over time is a cornerstone of normal systemic aging. The age-associated
arterial structural and functional changes in the intima, the media, and the adventitia are …