The imagistic evaluation of non-neovascular age-related macular degeneration (AMD) is
crucial for diagnosis, monitoring progression, and guiding management of the disease. Dry …

Purpose To quantify morphological changes of the photoreceptors (PRs) and retinal pigment
epithelium (RPE) layers under pegcetacoplan therapy in geographic atrophy (GA) using …

Clinical trials investigating drugs for various stages of age-related macular degeneration
(AMD) are actively underway and there is a strong interest in outcomes that demonstrate a …

Optical coherence tomography (OCT) allows noninvasive visualization of individual retinal
layers and has become a mainstay in the diagnosis and management of a wide range of …

Investigators have reported reduced visibility of the cone photoreceptors overlying drusen
using adaptive optics (AO) imaging techniques. Two hypotheses have been proposed to …

Purpose: To characterize the structure and function of patches of dysflective cones in the
foveal region of subjects with normal vision and no known pathology. Dysflective cones are …

Objective: This study used optical attenuation coefficient (OAC)-based optical coherence
tomography (OCT) en face images to assess the ellipsoid zone (EZ) in the foveal region …

Background Loss of function variants in the ornithine aminotransferase (OAT) gene cause
accumulation of ornithine levels, leading to gyrate atrophy. The benefit of ornithine-lowering …

Purpose: To survey the impact of directional reflectivity on structures within optical
coherence tomography (OCT) images in retinal pathology. Methods: Sets of commercial …

Many conditions either directly or indirectly interfere with normal photoreceptor function,
including inherited retinal conditions, systemic diseases, neurological disorders, and …