A tale of two viruses: the distinct spike glycoproteins of feline coronaviruses
Feline coronavirus (FCoV) is a complex viral agent that causes a variety of clinical
manifestations in cats, commonly known as feline infectious peritonitis (FIP). It is recognized …
manifestations in cats, commonly known as feline infectious peritonitis (FIP). It is recognized …
Molecular diversity of coronavirus host cell entry receptors
Coronaviruses are a group of viruses causing disease in a wide range of animals, and
humans. Since 2002, the successive emergence of bat-borne severe acute respiratory …
humans. Since 2002, the successive emergence of bat-borne severe acute respiratory …
Cryo-EM structures of SARS-CoV-2 spike without and with ACE2 reveal a pH-dependent switch to mediate endosomal positioning of receptor-binding domains
The SARS-CoV-2 spike employs mobile receptor-binding domains (RBDs) to engage the
human ACE2 receptor and to facilitate virus entry, which can occur through low-pH …
human ACE2 receptor and to facilitate virus entry, which can occur through low-pH …
Phylogenetic analysis and structural modeling of SARS-CoV-2 spike protein reveals an evolutionary distinct and proteolytically sensitive activation loop
Abstract The 2019 novel coronavirus (2019-nCoV/SARS-CoV-2) originally arose as part of a
major outbreak of respiratory disease centered on Hubei province, China. It is now a global …
major outbreak of respiratory disease centered on Hubei province, China. It is now a global …
Cryo-EM structure of a SARS-CoV-2 omicron spike protein ectodomain
The omicron variant of SARS-CoV-2 has been spreading rapidly across the globe. The virus-
surface spike protein plays a critical role in the cell entry and immune evasion of SARS-CoV …
surface spike protein plays a critical role in the cell entry and immune evasion of SARS-CoV …
Structural insights into coronavirus entry
MA Tortorici, D Veesler - Advances in virus research, 2019 - Elsevier
Coronaviruses (CoVs) have caused outbreaks of deadly pneumonia in humans since the
beginning of the 21st century. The severe acute respiratory syndrome coronavirus (SARS …
beginning of the 21st century. The severe acute respiratory syndrome coronavirus (SARS …
Molecular mechanism for antibody-dependent enhancement of coronavirus entry
Antibody-dependent enhancement (ADE) of viral entry has been a major concern for
epidemiology, vaccine development, and antibody-based drug therapy. However, the …
epidemiology, vaccine development, and antibody-based drug therapy. However, the …
Structural basis for human coronavirus attachment to sialic acid receptors
Coronaviruses cause respiratory tract infections in humans and outbreaks of deadly
pneumonia worldwide. Infections are initiated by the transmembrane spike (S) glycoprotein …
pneumonia worldwide. Infections are initiated by the transmembrane spike (S) glycoprotein …
Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2
The trimeric SARS coronavirus (SARS-CoV) surface spike (S) glycoprotein consisting of
three S1-S2 heterodimers binds the cellular receptor angiotensin-converting enzyme 2 …
three S1-S2 heterodimers binds the cellular receptor angiotensin-converting enzyme 2 …
[HTML][HTML] Unexpected receptor functional mimicry elucidates activation of coronavirus fusion
Recent outbreaks of severe acute respiratory syndrome and Middle East respiratory
syndrome, along with the threat of a future coronavirus-mediated pandemic, underscore the …
syndrome, along with the threat of a future coronavirus-mediated pandemic, underscore the …