Microfluidic devices for the isolation and label-free identification of circulating tumor cells

M Anwar, NM Reis, C Zhang, A Khan… - Chemical Engineering …, 2024 - Elsevier
The isolation and identification of circulating tumor cells (CTCs) from blood samples
provides a great opportunity for prevention of metastatic cancer and assist early diagnosis …

[HTML][HTML] Bile liquid biopsy in biliary tract cancer

F Liu, X Hao, B Liu, S Liu, Y Yuan - Clinica Chimica Acta, 2023 - Elsevier
Biliary tract cancers are heterogeneous in etiology, morphology and molecular
characteristics thus impacting disease management. Diagnosis is complex and prognosis …

[HTML][HTML] 3D-Nanostructured microfluidic device arranged in a herringbone pattern for the highly effective capture of HER2-Positive cancer-derived exosomes in urine

B Mun, H Jeong, R Kim, B Gu, J Kim, HY Son… - Chemical Engineering …, 2024 - Elsevier
Exosomes in body fluids are important in liquid biopsy as they reflect the information of their
originating cells. Thus, exosome analysis can provide valuable insights into diseases such …

Deep learning-assisted monitoring of trastuzumab efficacy in HER2-Overexpressing breast cancer via SERS immunoassays of tumor-derived urinary exosomal …

J Kim, HY Son, S Lee, HW Rho, R Kim, H Jeong… - Biosensors and …, 2024 - Elsevier
Monitoring drug efficacy is significant in the current concept of companion diagnostics in
metastatic breast cancer. Trastuzumab, a drug targeting human epidermal growth factor …

Colorimetric Detection of HER2‐Overexpressing‐Cancer‐Derived Exosomes in Mouse Urine Using Magnetic‐Polydiacetylene Nanoparticles

R Kim, B Mun, S Lim, C Park, J Kim, J Lim, H Jeong… - Small, 2024 - Wiley Online Library
Breast cancer (BC) is a major global health problem, with≈ 20–25% of patients
overexpressing human epidermal growth factor receptor 2 (HER2), an aggressive marker …

Portable Monitoring System for Assessing Therapeutic Efficacy in HER2‐Overexpressing Breast Cancer: One‐Step Simultaneous Detection of Cancer‐Derived …

R Kim, B Mun, J Lim, H Jeong, HY Son… - Advanced Functional …, 2024 - Wiley Online Library
Abstract Point‐of‐care (POC) monitoring of patient condition is crucial for effective cancer
treatment and prognosis. This can be achieved non‐invasively by analyzing exosomes in …

Microfluidic device with three-dimensional microtip electrodes for efficient capture and concentration of bacteria-sized microparticles using dielectrophoresis

YH Nam, SY Lee, SK Lee, JH Kim, JH Park - Sensors and Actuators A …, 2024 - Elsevier
Microfluidics-based systems have gained considerable attention in the lab-on-chip field
owing to their ability to separate, concentrate, and analyze microparticles. Concentrating …

Applications of dielectrophoresis in microfluidic-based exosome separation and detection

M Lan, F Yang - Chemical Engineering Journal, 2024 - Elsevier
Exosomes are small vesicles secreted by most cells with contents such as primitive cell
proteins, lipids, and RNAs, which play a key role in cell communication and could be …

Demystifying EV heterogeneity: emerging microfluidic technologies for isolation and multiplexed profiling of extracellular vesicles

G Zhang, X Huang, S Liu, Y Xu, N Wang, C Yang… - Lab on a Chip, 2025 - pubs.rsc.org
Extracellular vesicles (EVs) are heterogeneous lipid containers carrying complex molecular
cargoes, including proteins, nucleic acids, glycans, etc. These vesicles are closely …

The Latest Applications of Exosome-Mediated Drug Delivery in Anticancer Therapies

Z Wen, W Zhang, W Wu - Colloids and Surfaces B: Biointerfaces, 2025 - Elsevier
In recent years, the significant role of anticancer drugs in cancer treatment has garnered
considerable attention. However, the application of these drugs is largely limited by their …