Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration
Despite advances in uncovering the mechanisms that underlie neuroinflammation and
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …
Adenosine triggers early astrocyte reactivity that provokes microglial responses and drives the pathogenesis of sepsis-associated encephalopathy in mice
Q Guo, D Gobbo, N Zhao, H Zhang, NO Awuku… - Nature …, 2024 - nature.com
Molecular pathways mediating systemic inflammation entering the brain parenchyma to
induce sepsis-associated encephalopathy (SAE) remain elusive. Here, we report that in …
induce sepsis-associated encephalopathy (SAE) remain elusive. Here, we report that in …
Are we there yet? Exploring astrocyte heterogeneity one cell at a time
Astrocytes are a highly abundant cell type in the brain and spinal cord. Like neurons,
astrocytes can be molecularly and functionally distinct to fulfill specialized roles. Recent …
astrocytes can be molecularly and functionally distinct to fulfill specialized roles. Recent …
Gasdermin D activation in oligodendrocytes and microglia drives inflammatory demyelination in progressive multiple sclerosis
NM Pollock, JP Fernandes, J Woodfield… - Brain, Behavior, and …, 2024 - Elsevier
Neuroinflammation coupled with demyelination and neuro-axonal damage in the central
nervous system (CNS) contribute to disease advancement in progressive multiple sclerosis …
nervous system (CNS) contribute to disease advancement in progressive multiple sclerosis …
[HTML][HTML] An adhesion signaling axis involving Dystroglycan, β1-Integrin, and Cas adaptor proteins regulates the establishment of the cortical glial scaffold
W Wong, JA Estep, AM Treptow, N Rajabli… - PLoS …, 2023 - journals.plos.org
The mature mammalian cortex is composed of 6 architecturally and functionally distinct
layers. Two key steps in the assembly of this layered structure are the initial establishment of …
layers. Two key steps in the assembly of this layered structure are the initial establishment of …
[HTML][HTML] Protocol for the longitudinal study of neuroinflammation and reactive astrocytes in Lcn2CreERT2 mice
T Ubina, W Agnew-Svoboda, ZA Figueroa, EH Wilson… - STAR protocols, 2024 - Elsevier
During brain disease, astrocytes can reprogram into a reactive state that alters many of their
functions. Here, we present a protocol for studying neuroinflammation and reactive …
functions. Here, we present a protocol for studying neuroinflammation and reactive …
Adenosine triggers early astrocyte reactivity that provokes microglial activation and drives the pathogenesis of sepsis-associated encephalopathy
Q Guo, D Gobbo, N Zhao, Q Liu, LP Fang, TM Gampfer… - bioRxiv, 2023 - biorxiv.org
Molecular pathways mediating systemic inflammation entering the brain parenchyma to
induce sepsis-associated encephalopathy (SAE) remain elusive. Here, we report that in …
induce sepsis-associated encephalopathy (SAE) remain elusive. Here, we report that in …