Targeting immune cells in the tumor microenvironment of HCC: new opportunities and challenges

X Hao, G Sun, Y Zhang, X Kong, D Rong… - Frontiers in cell and …, 2021 - frontiersin.org
Immune associated cells in the microenvironment have a significant impact on the
development and progression of hepatocellular carcinoma (HCC) and have received more …

HBx-induced HSPA8 stimulates HBV replication and suppresses ferroptosis to support liver cancer progression

Y Wang, M Zhao, L Zhao, Y Geng, G Li, L Chen, J Yu… - Cancer Research, 2023 - AACR
Hepatitis B virus (HBV) infection is a major driver of hepatocarcinogenesis. Ferroptosis is a
type of iron-mediated cell death that can suppress liver transformation. Previous studies …

Circular RNA cFAM210A, degradable by HBx, inhibits HCC tumorigenesis by suppressing YBX1 transactivation

J Yu, W Li, G Hou, D Sun, Y Yang, S Yuan… - … & Molecular Medicine, 2023 - nature.com
Hepatitis B protein x (HBx) has been reported to promote tumorigenesis in hepatitis B virus
(HBV)-related hepatocellular carcinoma (HCC), but the mechanism awaits further …

Advancements in the alcohol-associated liver disease model

L Zhu, HD Li, JJ Xu, JJ Li, M Cheng, XM Meng… - Biomolecules, 2022 - mdpi.com
Alcohol-associated liver disease (ALD) is an intricate disease that results in a broad
spectrum of liver damage. The presentation of ALD can include simple steatosis …

SLC3A2 promotes tumor‐associated macrophage polarization through metabolic reprogramming in lung cancer

Z Li, S Chen, X He, S Gong, L Sun, L Weng - Cancer science, 2023 - Wiley Online Library
Tumor‐associated macrophages (TAMs) are one of the most abundant immunosuppressive
cells in the tumor microenvironment and possess crucial functions in facilitating tumor …

[HTML][HTML] Hexosamine biosynthetic pathway promotes the antiviral activity of SAMHD1 by enhancing O-GlcNAc transferase-mediated protein O-GlcNAcylation

J Hu, Q Gao, Y Yang, J Xia, W Zhang, Y Chen… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Viruses hijack the host cell machinery to promote viral replication; however, the
mechanism by which metabolic reprogramming regulates innate antiviral immunity in the …

PTTG1 reprograms asparagine metabolism to promote hepatocellular carcinoma progression

Q Zhou, L Li, F Sha, Y Lei, X Tian, L Chen, Y Chen… - Cancer Research, 2023 - AACR
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and has a
poor prognosis. Pituitary tumor transforming gene 1 (PTTG1) is highly expressed in HCC …

Activated Natural Killer Cells‐Dependent Dendritic Cells Recruitment and Maturation by Responsive Nanogels for Targeting Pancreatic Cancer Immunotherapy

J Deng, W Xu, S Lei, W Li, Q Li, K Li, J Lyu, J Wang… - Small, 2022 - Wiley Online Library
Although enormous success has been obtained for dendritic cells (DCs)‐mediated antigen‐
specific T cells anticancer immunotherapy in the clinic, it still faces major challenging …

[PDF][PDF] 乙型肝炎病毒X 基因及其变异促肝细胞癌的作用机制

周鑫宇, 柳东红, 蔡仕良, 陈宏森, 何奕达, 王瑞华… - 中国癌症防治 …, 2022 - zgazfz.com
原发性肝癌居我国非成熟死亡原因的首位, 其中肝细胞癌(hepatocellular carcinoma, HCC)
占90% 以上. 慢性乙型肝炎病毒(hepatitis B virus, HBV) 感染是HCC 发生的主要原因. HBV …

[HTML][HTML] Lipid phosphatase SAC1 suppresses hepatitis B virus replication through promoting autophagic degradation of virions

J Zheng, Y Deng, Z Wei, H Zou, X Wen, J Cai, S Zhang… - Antiviral Research, 2023 - Elsevier
Phosphatidylinositol lipids play vital roles in lipid signal transduction, membrane recognition,
vesicle transport, and viral replication. Previous studies have revealed that SAC1-like …