Hand, foot and mouth disease (HFMD): emerging epidemiology and the need for a vaccine strategy

S Aswathyraj, G Arunkumar, EK Alidjinou… - Medical microbiology and …, 2016 - Springer
Hand, foot, and mouth disease (HFMD) is a contagious viral disease and mainly affects
infants and young children. The main manifestations are fever, vesicular rashes on hand …

Coxsackievirus A16: epidemiology, diagnosis, and vaccine

Q Mao, Y Wang, X Yao, L Bian, X Wu… - Human vaccines & …, 2014 - Taylor & Francis
Coxsackievirus 16 (CA16) is one of the major pathogens associated with hand, foot, and
mouth disease (HFMD) in infants and young children. In recent years, CA16 and human …

Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo …

FC Zhu, FY Meng, JX Li, XL Li, QY Mao, H Tao… - The Lancet, 2013 - thelancet.com
Background A vaccine for enterovirus 71 (EV71) is needed to address the high burden of
disease associated with infection. We assessed the efficacy, safety, immunogenicity …

A combination vaccine comprising of inactivated enterovirus 71 and coxsackievirus A16 elicits balanced protective immunity against both viruses

Y Cai, Z Ku, Q Liu, Q Leng, Z Huang - Vaccine, 2014 - Elsevier
Abstract Enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are the two major causative
agents of hand, foot and mouth disease (HFMD), which is an infectious disease frequently …

A neonatal mouse model of coxsackievirus A16 for vaccine evaluation

Q Mao, Y Wang, R Gao, J Shao, X Yao, S Lang… - Journal of …, 2012 - Am Soc Microbiol
To evaluate vaccine efficacy in protecting against coxsackievirus A16 (CA16), which causes
human hand, foot, and mouth disease (HFMD), we established the first neonatal mouse …

A virus-like particle based bivalent vaccine confers dual protection against enterovirus 71 and coxsackievirus A16 infections in mice

Z Ku, Q Liu, X Ye, Y Cai, X Wang, J Shi, D Li, X Jin… - Vaccine, 2014 - Elsevier
Abstract Enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are responsible for hand,
foot and mouth disease which has been prevalent in Asia-Pacific regions, causing …

Identification of conserved neutralizing linear epitopes within the VP1 protein of coxsackievirus A16

J Shi, X Huang, Q Liu, Z Huang - Vaccine, 2013 - Elsevier
Abstract Coxsackievirus A16 (CA16) is a major causative agent of hand, foot, and mouth
disease. Immunization with inactivated whole-virus or recombinant virus-like particles (VLP) …

Viruses associated with pneumonia in adults

TC Cesario - Clinical infectious diseases, 2012 - academic.oup.com
Viral pneumonia, which is typically associated with disease in childhood, is increasingly
recognized as causing problems in adults. Certain viruses, such as influenza virus, can …

Active immunization with a Coxsackievirus A16 experimental inactivated vaccine induces neutralizing antibodies and protects mice against lethal infection

Y Cai, Q Liu, X Huang, D Li, Z Ku, Y Zhang, Z Huang - Vaccine, 2013 - Elsevier
Coxsackievirus A16 (CA16) is one of the main pathogens that cause hand, foot and mouth
disease, which frequently occurs in young children. A small percentage of patients infected …

[HTML][HTML] Global landscape of coxsackieviruses in human health

RS Machado, FN Tavares, IP Sousa Jr - Virus Research, 2024 - Elsevier
Coxsackieviruses-induced infections, particularly in infants and young children, are one of
the most important public health issues in low-and middle-income countries, where the …