Chronic pain in children and adolescents can be difficult for a single provider to manage in a
busy clinical setting. Part of this difficulty is that pediatric chronic pain not only impacts the …

5-Hydroxy-l-tryptophan (5-HTP) is the immediate precursor in the biosynthesis of 5-hydroxy-
tryptamine (5-HT; serotonin) from the essential amino acid l-tryptophan (l-Trp). The use of l …

Encyclopedia of Dietary Supplements presents peer-reviewed, objective entries that
rigorously examine the most significant scientific research on basic chemical, preclinical …

The hormone cortisol, activated by the fight-or-flight (stress) response, is emerging as a
major culprit in a variety of health problems. The Cortisol Connection explores the …

Although exogenous melatonin supplementation has been suggested to be effective for
episodic migraine prophylaxis, there is no conclusive evidence comparing the efficacy of …

5-Hydroxytryptophan (5-HTP) plays an important role in the regulation of emotion, behavior,
sleep, pain, body temperature, and other physiological functions. It is used in the treatment …

A parallel, randomized, double‐blind trial is reported, in which 78 patients with chronic
tension‐type headaches were treated with l‐5‐hydroxytryptophan (5‐HTP)(n= 43) or …

Written by one of the foremost experts on sports nutrition and performance, A Guide to
Understanding Dietary Supplements takes a critical look at the dietary supplement industry …

Objective. To assess the efficacy and tolerability of prophylactic drugs for chronic tension-
type headache (TTH) in adults. Methods. We searched several databases from inception to …

Advances in our understanding of the pathophysiology of migraine have resulted in
important breakthroughs in treatment. For example, understanding of the role of serotonin in …