Background: Mendelian randomization (MR) studies investigate the effect of genetic
variation in levels of an exposure on an outcome, thereby using genetic variation as an …

Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts,
play a critical role in the compartmentalization of signaling pathways. Physical segregation …

Background A reduction in the availability of cholesterol may limit the cellular proliferation
required for cancer growth and metastasis. We tested the hypothesis that statin use begun …

The burgeoning interest in the field of epigenetics has precipitated the need to develop
approaches to strengthen causal inference when considering the role of epigenetic …

Observational studies have reported inconsistent associations between circulating lipids
and breast cancer risk. Using results from> 400,000 participants in two-sample Mendelian …

Epidemiological studies have demonstrated that genetic, environmental, behavioral, and
clinical factors contribute to cardiovascular disease development. How these risk factors …

Background Cancer is emerging as a major problem globally, as it accounts for the second
cause of death despite medical advances. According to epidemiological and basic studies …

BACKGROUND Increased concentrations of remnant cholesterol are causally associated
with increased risk of ischemic heart disease. We tested the hypothesis that increased …

The ABCA1 protein mediates the transfer of cellular cholesterol across the plasma
membrane to apolipoprotein AI. Loss-of-function mutations in the ABCA1 gene induce …

Background: The increasing usage of statins (the 3-hydroxy-3-methylglutaryl-coenzyme A
reductase inhibitors) has revealed a number of unexpected beneficial effects, including a …