The endoplasmic reticulum: Homeostasis and crosstalk in retinal health and disease
The endoplasmic reticulum (ER) is the largest intracellular organelle carrying out a broad
range of important cellular functions including protein biosynthesis, folding, and trafficking …
range of important cellular functions including protein biosynthesis, folding, and trafficking …
Stress management at the ER: regulators of ER stress-induced apoptosis
The endoplasmic reticulum (ER) is an elaborate cellular organelle essential for cell function
and survival. Conditions that interfere with ER function lead to the accumulation and …
and survival. Conditions that interfere with ER function lead to the accumulation and …
New directions in ER stress-induced cell death
Endoplasmic reticulum (ER) stress has been implicated in the pathophysiology of many
diseases including heart disease, cancer and neurodegenerative diseases such as …
diseases including heart disease, cancer and neurodegenerative diseases such as …
Linking ER stress to autophagy: potential implications for cancer therapy
Different physiological and pathological conditions can perturb protein folding in the
endoplasmic reticulum, leading to a condition known as ER stress. ER stress activates a …
endoplasmic reticulum, leading to a condition known as ER stress. ER stress activates a …
ER stress and autophagy
WS Lee, WH Yoo, HJ Chae - Current molecular medicine, 2015 - ingentaconnect.com
Eukaryotic cells respond to various types of stresses caused by changes in the extracellular
environment. Intracellular factors, such as the accumulation of misfolded proteins in the …
environment. Intracellular factors, such as the accumulation of misfolded proteins in the …
The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases
M Li - Apoptosis, 2021 - Springer
P53 up-regulated modulator of apoptosis (PUMA), a pro-apoptotic BCL-2 homology 3 (BH3)-
only member of the BCL-2 family, is a direct transcriptional target of P53 that elicits …
only member of the BCL-2 family, is a direct transcriptional target of P53 that elicits …
2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells
MR Bauer, AC Joerger… - Proceedings of the …, 2016 - National Acad Sciences
The tumor suppressor p53 has the most frequently mutated gene in human cancers. Many of
p53's oncogenic mutants are just destabilized and rapidly aggregate, and are targets for …
p53's oncogenic mutants are just destabilized and rapidly aggregate, and are targets for …
The essential role of p53-up-regulated modulator of apoptosis (Puma) and its regulation by FoxO3a transcription factor in β-amyloid-induced neuron death
Neurodegeneration underlies the pathology of Alzheimer disease (AD). The molecules
responsible for such neurodegeneration in AD brain are mostly unknown. Recent findings …
responsible for such neurodegeneration in AD brain are mostly unknown. Recent findings …
Tribbles pseudokinase 3 induces both apoptosis and autophagy in amyloid-β-induced neuronal death
Amyloid-β (Aβ)-induced neuron death is considered central to the pathogenesis of
Alzheimer's disease (AD). Among several death modalities, autophagy and apoptosis play …
Alzheimer's disease (AD). Among several death modalities, autophagy and apoptosis play …