The adult immune system consists of cells that emerged at various times during ontogeny.
We aimed to define the relationship between developmental origin and composition of the …

Two-dimensional neuronal cultures have a limited ability to recapitulate the in vivo
environment of the brain. Here, we introduce a three-dimensional in vitro model for human …

Hematopoietic stem cell (HSC) mutations can result in clonal hematopoiesis (CH) with
heterogeneous clinical outcomes. Here, we investigate how the cell state preceding Tet2 …

Here we describe an in vitro co-culture system that can differentiate hematopoietic
progenitor populations to all major hematopoietic lineages at clonal level. We present both a …

Hematopoietic stem cells (HSCs) are rare cells on top of the differentiation hierarchy of
hematopoiesis. HSCs are unique in their combined capacity to differentiate into all mature …

Results Characterization of the Cis-regulatory landscape of GMPs in vivo To study how
inactivation of an epigenetic regulator may promote disease-associated programs, we …