Autoantibodies are frequently observed in healthy individuals. In a minority of these
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …

Tyrosine kinases relay signals from diverse leukocyte antigen receptors, innate immune
receptors, and cytokine receptors, and therefore mediate the recruitment and activation of …

This guideline has been initiated by the task force Autoimmune Blistering Diseases of the
European Academy of Dermatology and Venereology, including physicians from all relevant …

Epidermolysis bullosa acquisita (EBA) is an orphan autoimmune disease. Patients with EBA
suffer from chronic inflammation as well as blistering and scarring of the skin and mucous …

Autoimmune skin blistering diseases (AIBD) are characterized by autoantibodies that are
directed against structural proteins in the skin and adjacent mucous membranes. Some …

Importance Bullous pemphigoid (BP) is by far the most frequent autoimmune blistering
disease. The presence of IgE autoantibodies against the transmembrane protein BP antigen …

IL-17A has been identified as key regulatory molecule in several autoimmune and chronic
inflammatory diseases followed by the successful use of anti-IL-17 therapy, eg in ankylosing …

The dermal‐epidermal junction consists of a network of several interacting structural
proteins that strengthen adhesion and mediate signalling events. This structural network …

The deposition of IgG autoantibodies in peripheral tissues and the subsequent activation of
the complement system, which leads to the accumulation of the anaphylatoxin C5a in these …

Bullous pemphigoid (BP) is by far the most common autoimmune blistering dermatosis that
mainly occurs in the elderly. The BP180 is a transmembrane glycoprotein, which is highly …