Natural killer T (NKT) cells are innate-like T cells that rapidly produce a variety of cytokines
following T cell receptor (TCR) activation and can shape the immune response in many …

Natural killer T cells (NKT cells) are CD1d-restricted, lipid antigen–reactive,
immunoregulatory T lymphocytes that can promote cell-mediated immunity to tumors and …

Mucosal-associated invariant T cells (MAIT cells) express a semi-invariant T cell receptor
(TCR) α-chain, TRAV1-2–TRAJ33, and are activated by vitamin B metabolites bound by the …

T lymphocytes expressing γδ T cell antigen receptors (TCRs) comprise evolutionarily
conserved cells with paradoxical features. On the one hand, clonally expanded γδ T cells …

Control of infection with Mycobacterium tuberculosis (Mtb) requires Th1-type immunity, of
which CD8+ T cells play a unique role. High frequency Mtb-reactive CD8+ T cells are …

Mucosal-associated invariant T (MAIT) cells express an invariant T cell receptor (TCR) α-
chain (TRAV1-2 joined to TRAJ33, TRAJ20, or TRAJ12 in humans), which pairs with an …

Invariant natural killer T cells (i NKT cells) have a prominent role during infection and other
inflammatory processes, and these cells can be activated through their T cell antigen …

A characteristic of mucosal-associated invariant T (MAIT) cells is the expression of TRAV1-
2+ T cell receptors (TCRs) that are activated by riboflavin metabolite-based antigens (Ag) …

MR1-restricted T cells (MR1Ts) are a T cell subset that recognize and mediate host defense
to a broad array of microbial pathogens, including respiratory pathogens (eg …

The semi-invariant natural killer T cell receptor (NKT TCR) recognizes CD1d-lipid antigens.
Although the TCRα chain is typically invariant, the β chain expression is more diverse …