Abstract Alzheimer's disease (AD), being the number one in terms of dementia burden, is an
insidious age-related neurodegenerative disease and is presently considered a global …

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized
by the degeneration of both upper and lower motor neurons, which leads to muscle …

Metabolites, the biochemical products of the cellular process, can be used to measure
alterations in biochemical pathways related to the pathogenesis of Alzheimer's disease …

Abstract See Grinberg and Heinsen (doi: 10.1093/brain/awx261) for a scientific commentary
on this article. Clinical evidence suggests that aberrant tau accumulation in the locus …

Nanotechnology is one of the methods that influenced human life in different ways and is a
substantial approach that assists to overcome the multiple limitations of various diseases …

Germline mutations in cellular-energy associated genes have been shown to lead to various
monogenic disorders. Notably, mitochondrial disorders often impact skeletal muscle, brain …

Extracellular vesicles (EVs) are highly diverse nanoscale membrane-bound structures
released from different cell types into the extracellular environment. They play essential …

Two-dimensional (2D) porphyrin-based metal–organic frameworks (MOFs) hold great
promise in a variety of areas with the merits of large lateral size and abundant functional …

There is a dire need to discover new targets for Alzheimer's disease (AD) drug development.
Decreased neuronal glucose metabolism that occurs in AD brain could play a central role in …

The fight against neurodegenerative diseases, Alzheimer disease and Parkinson's disease
(PD), is a challenge of the 21st century. The low efficacy of treating patients is due to the late …