Background Diabetic foot ulcer (DFU) is one of the diabetes complications. DFU can be the
cause of a high rate of amputation, health-care costs and even death, and this condition …

The dysregulated phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target of rapamycin
(mTOR) signaling pathway has been implicated in various immune-mediated inflammatory …

Background: Skin wound healing is a challenging problem, especially in aging or diabetic
patients, which becomes more difficult to heal, and easily results in considerable public …

Cutaneous wounds are among the most common soft tissue injuries and are particularly
hard to heal in aging. Caloric restriction (CR) is well documented to extend longevity; …

Introduction Cell therapy with mesenchymal stem cells (MSCs) and biomaterials holds great
potential for the treatment of diabetic ulceration; however, the underlying mechanism as well …

Burns can be caused by various factors and have an increased risk of infection that can
seriously delay the wound healing process. Chronic wounds caused by burns represent a …

Wound healing impairment is increasingly recognized to be a consequence of
hyperglycemia‑induced dysfunction of endothelial precursor cells (EPCs) in type 2 diabetes …

Objective The aim of this study was to develop a chitosan-metformin based intrapocket
dental film (CMIDF) for applications in the treatment of periodontitis and alveolar bone loss …

Diabetes and periodontitis are two of the most prevalent diseases worldwide that negatively
impact the quality of life of the individual suffering from them. They are part of the chronic …

Metformin has been used for the treatment of type II diabetes mellitus for decades. Recently,
used of metformin in the therapy of diverse human cancer types has received widespread …