Genome-wide association studies
Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …
across many genomes to find those statistically associated with a specific trait or disease …
[HTML][HTML] Genetic architecture of ADHD and overlap with other psychiatric disorders and cognition-related phenotypes
Attention-deficit/hyperactivity disorder (ADHD) co-occurs with many other psychiatric
disorders and traits. In this review, we summarize and interpret the existing literature on the …
disorders and traits. In this review, we summarize and interpret the existing literature on the …
An integrated framework for local genetic correlation analysis
J Werme, S van der Sluis, D Posthuma, CA de Leeuw - Nature genetics, 2022 - nature.com
Genetic correlation (rg) analysis is used to identify phenotypes that may have a shared
genetic basis. Traditionally, rg is studied globally, considering only the average of the …
genetic basis. Traditionally, rg is studied globally, considering only the average of the …
Role of the gut-brain axis in the shared genetic etiology between gastrointestinal tract diseases and psychiatric disorders: A genome-wide pleiotropic analysis
Importance Comorbidities and genetic correlations between gastrointestinal tract diseases
and psychiatric disorders have been widely reported, with the gut-brain axis (GBA) …
and psychiatric disorders have been widely reported, with the gut-brain axis (GBA) …
Genetic relationships between attention-deficit/hyperactivity disorder, autism spectrum disorder, and intelligence
S Rao, A Baranova, Y Yao, J Wang, F Zhang - Neuropsychobiology, 2022 - karger.com
Introduction: Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder
(ASD) commonly co-occur; both traits exert an influence on intelligence scores. Genetic …
(ASD) commonly co-occur; both traits exert an influence on intelligence scores. Genetic …
Multi-trait and cross-population genome-wide association studies across autoimmune and allergic diseases identify shared and distinct genetic component
Y Shirai, Y Nakanishi, A Suzuki, H Konaka… - Annals of the …, 2022 - ard.bmj.com
Objectives Autoimmune and allergic diseases are outcomes of the dysregulation of the
immune system. Our study aimed to elucidate differences or shared components in genetic …
immune system. Our study aimed to elucidate differences or shared components in genetic …
Estimating genetic nurture with summary statistics of multigenerational genome-wide association studies
Marginal effect estimates in genome-wide association studies (GWAS) are mixtures of direct
and indirect genetic effects. Existing methods to dissect these effects require family-based …
and indirect genetic effects. Existing methods to dissect these effects require family-based …
Comparison of methods for estimating genetic correlation between complex traits using GWAS summary statistics
Genetic correlation is the correlation of phenotypic effects by genetic variants across the
genome on two phenotypes. It is an informative metric to quantify the overall genetic …
genome on two phenotypes. It is an informative metric to quantify the overall genetic …
Discovering non-additive heritability using additive GWAS summary statistics
LD score regression (LDSC) is a method to estimate narrow-sense heritability from genome-
wide association study (GWAS) summary statistics alone, making it a fast and popular …
wide association study (GWAS) summary statistics alone, making it a fast and popular …
Diabetes and Alzheimer's disease: shared genetic susceptibility?
J Hardy, B de Strooper, V Escott-Price - The Lancet Neurology, 2022 - thelancet.com
A search of PubMed using the terms “diabetes” and “Alzheimer's disease” yields nearly
9000 articles, suggesting that a mechanistic link between these two common diseases …
9000 articles, suggesting that a mechanistic link between these two common diseases …