[PDF][PDF] Serum hepatitis B virus RNA: a new potential biomarker for chronic hepatitis B virus infection
S Liu, B Zhou, JD Valdes, J Sun, H Guo - Hepatology, 2019 - Wiley Online Library
Chronic hepatitis B infection is one of the major etiological causes of liver failure, cirrhosis,
and hepatocellular carcinoma (HCC) worldwide. This condition cannot be completely cured …
and hepatocellular carcinoma (HCC) worldwide. This condition cannot be completely cured …
Novel biomarkers of hepatitis B virus and their use in chronic hepatitis B patient management
A Vachon, C Osiowy - Viruses, 2021 - mdpi.com
Even though an approved vaccine for hepatitis B virus (HBV) is available and widely used,
over 257 million individuals worldwide are living with chronic hepatitis B (CHB) who require …
over 257 million individuals worldwide are living with chronic hepatitis B (CHB) who require …
Hepatitis B virus capsid assembly modulators, but not nucleoside analogs, inhibit the production of extracellular pregenomic RNA and spliced RNA variants
AM Lam, S Ren, C Espiritu, M Kelly, V Lau… - Antimicrobial agents …, 2017 - Am Soc Microbiol
The hepatitis B virus (HBV) core protein serves multiple essential functions in the viral life
cycle, and antiviral agents that target the core protein are being developed. Capsid …
cycle, and antiviral agents that target the core protein are being developed. Capsid …
Biogenesis and molecular characteristics of serum hepatitis B virus RNA
HBV is an enveloped DNA virus that replicates its DNA genome via reverse transcription of a
pregenomic (pg) RNA intermediate in hepatocytes. Interestingly, HBV RNA can be detected …
pregenomic (pg) RNA intermediate in hepatocytes. Interestingly, HBV RNA can be detected …
Extracellular hepatitis B virus RNAs are heterogeneous in length and circulate as capsid-antibody complexes in addition to virions in chronic hepatitis B patients
L Bai, X Zhang, M Kozlowski, W Li, M Wu, J Liu… - Journal of …, 2018 - Am Soc Microbiol
Extracellular HBV RNA has been detected in both HBV-replicating cell culture media and
sera from chronic hepatitis B (CHB) patients, but its exact origin and composition remain …
sera from chronic hepatitis B (CHB) patients, but its exact origin and composition remain …
Conditional replication and secretion of hepatitis B virus genome uncover the truncated 3′ terminus of encapsidated viral pregenomic RNA
Hepatitis B virus (HBV) pregenomic RNA (pgRNA) is packaged into capsid where reverse
transcription takes place to synthesize viral DNA genome, and the encapsidated pgRNA is …
transcription takes place to synthesize viral DNA genome, and the encapsidated pgRNA is …
Activation of stimulator of interferon genes in hepatocytes suppresses the replication of hepatitis B virus
Induction of interferon and proinflammatory cytokines is a hallmark of the infection of many
different viruses. However, hepatitis B virus (HBV) does not elicit a detectable cytokine …
different viruses. However, hepatitis B virus (HBV) does not elicit a detectable cytokine …
[PDF][PDF] Hepatitis B virus virions produced under nucleos (t) ide analogue treatment are mainly not infectious because of irreversible DNA chain termination
Nucleos (t) ide analogues (NAs) have been widely used for the treatment of chronic hepatitis
B (CHB). Because viral DNA polymerase lacks proofreading function (3′ exonuclease …
B (CHB). Because viral DNA polymerase lacks proofreading function (3′ exonuclease …
The current status and future directions of hepatitis B antiviral drug discovery
Introduction: The current standard care of chronic hepatitis B fails to induce a durable off-
drug control of hepatitis B virus (HBV) replication in the majority of treated patients. The …
drug control of hepatitis B virus (HBV) replication in the majority of treated patients. The …
Virological basis for the cure of chronic hepatitis B
Hepatitis B virus (HBV) has infected one-third of world population, and 240 million people
are chronic carriers, to whom a curative therapy is still not available. Similar to other viruses …
are chronic carriers, to whom a curative therapy is still not available. Similar to other viruses …