Multidrug resistance in Escherichia coli has become a worrying issue that is increasingly
observed in human but also in veterinary medicine worldwide. E. coli is intrinsically …

Leishmaniasis is a zoonotic disease in humans caused by the bite of a parasite-infected
sandfly. The disease, widely referred to as “poor man's disease,” affects millions of people …

Shigella spp. are a common cause of diarrheal disease and have remained an important
pathogen responsible for increased rates of morbidity and mortality caused by dysentery …

Crystal structures of the 30 S ribosomal subunit in complex with messenger RNA and
cognate transfer RNA in the A site, both in the presence and absence of the antibiotic …

Aminoglycoside antibiotics have had a major impact on our ability to treat bacterial infections
for the past half century. Whereas the interest in these versatile antibiotics continues to be …

The small ribosomal subunit performs the decoding of genetic information during translation.
The structure of that from Thermus thermophilus shows that the decoding center, which …

Aminoglycosides are among the most commonly used broad-spectrum antibiotics in the anti-
infective armamentarium. The vast majority of aminoglycosides are bactericidal, they have …

Following the discovery of penicillin, which was inactive against Mycobacterium
tuberculosis, Waksman discovered the first antituberculosis agent, streptomycin, by …

▪ Abstract The underlying basis for the accuracy of protein synthesis has been the subject of
over four decades of investigation. Recent biochemical and structural data make it possible …

Abstract Changes to the conformation of coding and non-coding RNAs form the basis of
elements of genetic regulation and provide an important source of complexity, which drives …