Huntington's disease: a clinical review

P McColgan, SJ Tabrizi - European journal of neurology, 2018 - Wiley Online Library
Huntington's disease (HD) is a fully penetrant neurodegenerative disease caused by a
dominantly inherited CAG trinucleotide repeat expansion in the huntingtin gene on …

An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders

NJ Ashton, A Hye, AP Rajkumar, A Leuzy… - Nature Reviews …, 2020 - nature.com
Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology
at the earliest stage of some neurodegenerative disorders, but do not have the scalability …

Hybrid gene selection approach using XGBoost and multi-objective genetic algorithm for cancer classification

X Deng, M Li, S Deng, L Wang - Medical & Biological Engineering & …, 2022 - Springer
Microarray gene expression data are often accompanied by a large number of genes and a
small number of samples. However, only a few of these genes are relevant to cancer …

Huntington's disease

FO Walker - The Lancet, 2007 - thelancet.com
Huntington's disease is an autosomal-dominant, progressive neurodegenerative disorder
with a distinct phenotype, including chorea and dystonia, incoordination, cognitive decline …

Molecular mechanisms and potential therapeutical targets in Huntington's disease

C Zuccato, M Valenza, E Cattaneo - Physiological reviews, 2010 - journals.physiology.org
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

Mass spectrometric based approaches in urine metabolomics and biomarker discovery

MM Khamis, DJ Adamko… - Mass spectrometry …, 2017 - Wiley Online Library
Urine metabolomics has recently emerged as a prominent field for the discovery of non‐
invasive biomarkers that can detect subtle metabolic discrepancies in response to a specific …

Long non-coding RNAs in Huntington's disease neurodegeneration

R Johnson - Neurobiology of disease, 2012 - Elsevier
Neurodegeneration in the brains of Huntington's disease patients is accompanied by
widespread changes in gene regulatory networks. Recent studies have found that these …

Epigenetic and immune function profiles associated with posttraumatic stress disorder

M Uddin, AE Aiello, DE Wildman… - Proceedings of the …, 2010 - National Acad Sciences
The biologic underpinnings of posttraumatic stress disorder (PTSD) have not been fully
elucidated. Previous work suggests that alterations in the immune system are characteristic …

EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans

A Van Hoecke, L Schoonaert, R Lemmens… - Nature medicine, 2012 - nature.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting motor
neurons. Disease onset and progression are variable, with survival ranging from months to …

Beyond the brain: widespread pathology in Huntington's disease

JMM van der Burg, M Björkqvist, P Brundin - The Lancet Neurology, 2009 - thelancet.com
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by a
polyglutamine stretch in the huntingtin protein. Today, more than 15 years after the genetic …