The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus
GB Karlsson Hedestam, RAM Fouchier… - Nature Reviews …, 2008 - nature.com
The ability to elicit broadly neutralizing antibody responses against HIV-1 is a crucial goal for
a prophylactic HIV-1 vaccine. Here, we discuss the difficulties of achieving broad HIV-1 …
a prophylactic HIV-1 vaccine. Here, we discuss the difficulties of achieving broad HIV-1 …
The many mechanisms of viral membrane fusion proteins
LJ Earp, SE Delos, HE Park, JM White - Membrane trafficking in viral …, 2005 - Springer
Every enveloped virus fuses its membrane with a host cell membrane, thereby releasing its
genome into the cytoplasm and initiating the viral replication cycle. In each case, one or a …
genome into the cytoplasm and initiating the viral replication cycle. In each case, one or a …
Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01
During HIV-1 infection, antibodies are generated against the region of the viral gp120
envelope glycoprotein that binds CD4, the primary receptor for HIV-1. Among these …
envelope glycoprotein that binds CD4, the primary receptor for HIV-1. Among these …
Envelope residue 375 substitutions in simian–human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques
H Li, S Wang, R Kong, W Ding… - Proceedings of the …, 2016 - National Acad Sciences
Most simian–human immunodeficiency viruses (SHIVs) bearing envelope (Env)
glycoproteins from primary HIV-1 strains fail to infect rhesus macaques (RMs). We …
glycoproteins from primary HIV-1 strains fail to infect rhesus macaques (RMs). We …
Interaction with cellular CD4 exposes HIV-1 envelope epitopes targeted by antibody-dependent cell-mediated cytotoxicity
M Veillette, A Désormeaux, H Medjahed… - Journal of …, 2014 - Am Soc Microbiol
ABSTRACT Anti-HIV-1 envelope glycoprotein (Env) antibodies without broadly neutralizing
activity correlated with protection in the RV144 clinical trial, stimulating interest in other …
activity correlated with protection in the RV144 clinical trial, stimulating interest in other …
Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility
M Pancera, S Majeed, YEA Ban… - Proceedings of the …, 2010 - National Acad Sciences
The viral spike of HIV-1 is composed of three gp120 envelope glycoproteins attached
noncovalently to three gp41 transmembrane molecules. Viral entry is initiated by binding to …
noncovalently to three gp41 transmembrane molecules. Viral entry is initiated by binding to …
Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops
The HIV-1 envelope (Env) spike (gp1203/gp413) undergoes considerable structural
rearrangements to mediate virus entry into cells and to evade the host immune response …
rearrangements to mediate virus entry into cells and to evade the host immune response …
Principles and practical applications of structure-based vaccine design
PO Byrne, JS McLellan - Current opinion in immunology, 2022 - Elsevier
Highlights•Summary of the basic principles of structure-based vaccine design.•Review of
recent advances (the years 2019–2021) in structure-based vaccine design.•Preview of …
recent advances (the years 2019–2021) in structure-based vaccine design.•Preview of …
Antigenic conservation and immunogenicity of the HIV coreceptor binding site
JM Decker, F Bibollet-Ruche, X Wei, S Wang… - The Journal of …, 2005 - rupress.org
Immunogenic, broadly reactive epitopes of the HIV-1 envelope glycoprotein could serve as
important targets of the adaptive humoral immune response in natural infection and …
important targets of the adaptive humoral immune response in natural infection and …
Topological layers in the HIV-1 gp120 inner domain regulate gp41 interaction and CD4-triggered conformational transitions
The entry of human immunodeficiency virus (HIV-1) into cells is initiated by binding of the
gp120 exterior envelope glycoprotein to the receptor, CD4. How does CD4 binding trigger …
gp120 exterior envelope glycoprotein to the receptor, CD4. How does CD4 binding trigger …