The genotype–fitness map (that is, the fitness landscape) is a key determinant of evolution,
yet it has mostly been used as a superficial metaphor because we know little about its …

The face of evolutionary biology is changing: from reconstructing and analysing the past to
predicting future evolutionary processes. Recent developments include prediction of …

Mutations in non-coding regulatory DNA sequences can alter gene expression, organismal
phenotype and fitness,–. Constructing complete fitness landscapes, in which DNA …

Over the last decade, a rich variety of massively parallel assays have revolutionized our
understanding of how biological sequences encode quantitative molecular phenotypes …

The concept of a fitness landscape is a powerful metaphor that offers insight into various
aspects of evolutionary processes and guidance for the study of evolution. Until recently …

Evolution is a quest for innovation. Organisms adapt to changing natural selection by
evolving new phenotypes. Can we read this dynamics in their genomes? Not every mutation …

Promoters play an essential role in the regulation of gene expression for fine-tuning genetic
circuits and metabolic pathways in Saccharomyces cerevisiae (S. cerevisiae). However …

Gene expression is controlled primarily by transcription factors, whose DNA binding sites
are typically 10 nt long. We develop a population-genetic model to understand how the …

We employ a biophysical model that accounts for the non-linear relationship between
binding energy and the statistics of selected binding sites. The model includes the chemical …

The efficient recognition of pathogens by the adaptive immune system relies on the diversity
of receptors displayed at the surface of immune cells. T-cell receptor diversity results from an …