Zebrafish as a model system to study the mechanism of cutaneous wound healing and drug discovery: advantages and challenges

R Naomi, H Bahari, MD Yazid, H Embong, F Othman - Pharmaceuticals, 2021 - mdpi.com
In humans, cutaneous wounds may heal without scars during embryogenesis. However, in
the adult phase, the similar wound may undergo a few events such as homeostasis, blood …

[HTML][HTML] Are synthetic glucocorticoids in the aquatic environment a risk to fish?

CM Hamilton, MJ Winter, L Margiotta-Casaluci… - Environment …, 2022 - Elsevier
The glucocorticosteroid, or glucocorticoid (GC), system is largely conserved across
vertebrates and plays a central role in numerous vital physiological processes including …

Photobiomodulation with pulsed and continuous wave near-infrared laser (810 nm, Al-Ga-As) augments dermal wound healing in immunosuppressed rats

GK Keshri, A Gupta, A Yadav, SK Sharma, SB Singh - PloS one, 2016 - journals.plos.org
Chronic non-healing cutaneous wounds are often vulnerable in one or more repair phases
that prevent normal healing and pose challenges to the use of conventional wound care …

Inhibitory effects of polystyrene microplastics on caudal fin regeneration in zebrafish larvae

L Gu, L Tian, G Gao, S Peng, J Zhang, D Wu… - Environmental …, 2020 - Elsevier
Microplastic pollution is pervasive in aquatic environments, but the potential effects of
microplastics on aquatic organisms are still under debate. Given that tissue damage is …

Prolonged exposure to the synthetic glucocorticoid dexamethasone induces brain damage via oxidative stress and apoptotic response in adult Danio rerio

LM Sanchez-Aceves, I Pérez-Alvarez… - Chemosphere, 2024 - Elsevier
Due to its extensive use as a painkiller, anti-inflammatory, and immune modulatory agent, as
well as its effectiveness in treating severe COVID-19, dexamethasone, a synthetic …

Immune suppressive and bone inhibitory effects of prednisolone in growing and regenerating zebrafish tissues

K Geurtzen, A Vernet, A Freidin… - Journal of Bone and …, 2017 - academic.oup.com
Glucocorticoids are widely used as therapeutic agents to treat immune‐mediated diseases
in humans because of their anti‐inflammatory and immunosuppressive effects. However …

Hypericum lanceolatum Lam. Medicinal Plant: Potential Toxicity and Therapeutic Effects Based on a Zebrafish Model

L Gence, D Fernezelian, M Bringart, B Veeren… - Frontiers in …, 2022 - frontiersin.org
Hypericum lanceolatum Lam.(H. lanceolatum) is a traditional medicinal plant from Reunion
Island used for its pleiotropic effects mainly related to its antioxidant activity. The present …

[HTML][HTML] Guarea microcarpa C. DC. extract inhibits NLRP3 inflammasome by suppressing its ATPase activity

S Lee, S Yun, H Yang, N Lee, YJ Kim, S Lee… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Guarea genus comprises tropical and subtropical
terrestrial herbs inhabiting Central and South America. These plants, including Guarea …

Fenobucarb-induced developmental neurotoxicity and mechanisms in zebrafish

XY Zhu, YY Wu, B Xia, MZ Dai, YF Huang, H Yang… - Neurotoxicology, 2020 - Elsevier
Abstract Fenobucarb (2-sec-butylphenyl methylcarbamate, BPMC) is an extensively used
carbamate insecticide. Its developmental neurotoxicity and the underlying mechanisms have …

Spirulina maxima derived marine pectin promotes the in vitro and in vivo regeneration and wound healing in zebrafish

SL Edirisinghe, DC Rajapaksha, C Nikapitiya… - Fish & Shellfish …, 2020 - Elsevier
Purified bioactive components of marine algae have shown great pharmaceutical and
biomedical potential, including wound healing activity. However, the activity of Spirulina …