Liquid–liquid phase separation in human health and diseases
Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital
and ubiquitous phenomenon underlying the formation of membraneless organelles in …
and ubiquitous phenomenon underlying the formation of membraneless organelles in …
The natural history, pathobiology, and clinical manifestations of SARS-CoV-2 infections
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of
coronavirus disease 2019 (COVID-19). SARS-CoV-2, is a positive-sense single-stranded …
coronavirus disease 2019 (COVID-19). SARS-CoV-2, is a positive-sense single-stranded …
The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein
The multifunctional nucleocapsid (N) protein in SARS-CoV-2 binds the~ 30 kb viral RNA
genome to aid its packaging into the 80–90 nm membrane-enveloped virion. The N protein …
genome to aid its packaging into the 80–90 nm membrane-enveloped virion. The N protein …
The molecular virology of coronaviruses
E Hartenian, D Nandakumar, A Lari, M Ly… - Journal of Biological …, 2020 - ASBMB
Few human pathogens have been the focus of as much concentrated worldwide attention as
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its …
Phosphoregulation of phase separation by the SARS-CoV-2 N protein suggests a biophysical basis for its dual functions
The nucleocapsid (N) protein of coronaviruses serves two major functions: compaction of the
RNA genome in the virion and regulation of viral gene transcription. It is not clear how the N …
RNA genome in the virion and regulation of viral gene transcription. It is not clear how the N …
Overview of SARS-CoV-2 genome-encoded proteins
C Bai, Q Zhong, GF Gao - Science China Life Sciences, 2022 - Springer
Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) has spread rapidly
throughout the world. SARS-CoV-2 is an enveloped, plus-stranded RNA virus with a single …
throughout the world. SARS-CoV-2 is an enveloped, plus-stranded RNA virus with a single …
Human coronavirus: host-pathogen interaction
TS Fung, DX Liu - Annual review of microbiology, 2019 - annualreviews.org
Human coronavirus (HCoV) infection causes respiratory diseases with mild to severe
outcomes. In the last 15 years, we have witnessed the emergence of two zoonotic, highly …
outcomes. In the last 15 years, we have witnessed the emergence of two zoonotic, highly …
Structures of the SARS‐CoV‐2 nucleocapsid and their perspectives for drug design
Y Peng, N Du, Y Lei, S Dorje, J Qi, T Luo, GF Gao… - The EMBO …, 2020 - embopress.org
Abstract COVID‐19, caused by SARS‐CoV‐2, has resulted in severe and unprecedented
economic and social disruptions in the world. Nucleocapsid (N) protein, which is the major …
economic and social disruptions in the world. Nucleocapsid (N) protein, which is the major …
Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design
B Malone, N Urakova, EJ Snijder… - … Reviews Molecular Cell …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed millions of
people and continues to cause massive global upheaval. Coronaviruses are positive-strand …
people and continues to cause massive global upheaval. Coronaviruses are positive-strand …
Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis
While SARS-CoV-2 continues to adapt for human infection and transmission, genetic
variation outside of the spike gene remains largely unexplored. This study investigates a …
variation outside of the spike gene remains largely unexplored. This study investigates a …