Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

Hydrogen/deuterium exchange (HDX) detected by mass spectrometry (MS) is extraordinarily
useful in the study of many aspects of proteins, especially the analysis of protein …

Hydrogen/deuterium exchange mass spectrometry (HDX-MS) has within the last 25 years
evolved to become a well-established technique for analysing the solution-phase …

All processes that occur within living organisms are intimately linked to biological
macromolecules such as proteins, nucleic acids, or polysaccharides. Phospholipid …

Hydrogen deuterium exchange mass spectrometry (HDX-MS) is becoming part of the
standard repertoire of techniques used by molecular biologists to investigate protein …

Hydrogen/deuterium exchange mass spectrometry (HDX-MS) probes dynamic motions of
proteins by monitoring the kinetics of backbone amide deuteration. Dynamic regions exhibit …

This article reviews the analytical aspects of measuring hydrogen exchange by mass
spectrometry (HX MS). We describe the nature of analytical selectivity in hydrogen …

During the analysis steps of hydrogen–deuterium exchange (HDX) mass spectrometry (MS),
there is an unavoidable loss of deuterons, or back-exchange. Understanding back …

The recycling of immunoglobulins by the neonatal Fc receptor (FcRn) is of crucial
importance in the maintenance of antibody levels in plasma and is responsible for the long …

Abstract Characterization of therapeutic drugs is a crucial step in drug development in the
biopharmaceutical industry. Analysis of protein therapeutics is a challenging task because of …