Central 5-HT receptors and their function; present and future

T Sharp, NM Barnes - Neuropharmacology, 2020 - Elsevier
Since our review of central 5-HT receptors and their function twenty years ago, no new 5-HT
receptor has been discovered and there is little evidence that this situation will change in the …

5-HT3 receptor antagonists in neurologic and neuropsychiatric disorders: the iceberg still lies beneath the surface

G Fakhfouri, R Rahimian, J Dyhrfjeld-Johnsen… - Pharmacological …, 2019 - ASPET
5-HT3 receptor antagonists, first introduced to the market in the mid-1980s, are proven
efficient agents to counteract chemotherapy-induced emesis. Nonetheless, recent …

Thymol reverses depression-like behaviour and upregulates hippocampal BDNF levels in chronic corticosterone-induced depression model in female mice

VCC Capibaribe… - Journal of Pharmacy …, 2019 - academic.oup.com
Objectives Based on this, the central therapeutic effects of thymol were verified in the
neurotrophic pathway. Methods Female swiss mice were divided into four groups: control …

Modulation of the serotonergic receptosome in the treatment of anxiety and depression: a narrative review of the experimental evidence

GR Villas-Boas, SN Lavorato, MM Paes… - Pharmaceuticals, 2021 - mdpi.com
Serotonin (5-HT) receptors are found throughout central and peripheral nervous systems,
mainly in brain regions involved in the neurobiology of anxiety and depression. 5-HT …

Inhaled Litsea glaucescens K.(Lauraceae) leaves' essential oil has anxiolytic and antidepressant-like activity in mice by BDNF pathway activation.

JK Díaz-Cantón, MA Torres-Ramos… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Litsea glaucescens K.(Lauraceae) is a small tree from the
Mexican and Central American temperate forests, named as “Laurel”. Its aromatic leaves are …

5HT3 receptors: Target for new antidepressant drugs

D Gupta, V Prabhakar, M Radhakrishnan - Neuroscience & Biobehavioral …, 2016 - Elsevier
Abstract 5HT 3 receptors (5HT3Rs) have long been identified as a potential target for
antidepressants. Several studies have reported that antagonism of 5HT3Rs produces …

Current and future perspectives on the major depressive disorder: focus on the new multimodal antidepressant vortioxetine

L Orsolini, C Tomasetti, A Valchera… - CNS & Neurological …, 2017 - ingentaconnect.com
Background: Vortioxetine (VRX) is a multimodal antidepressant that acts as serotonin (5HT)
transporter inhibitor as well as 5HT3A and 5HT7 receptors antagonist, 5HT1A and 5HT1B …

Regional distribution of serotonergic receptors: a systems neuroscience perspective on the downstream effects of the multimodal-acting antidepressant vortioxetine on …

AL Pehrson, T Jeyarajah, C Sanchez - CNS spectrums, 2016 - cambridge.org
Previous work from this laboratory hypothesized that the multimodal antidepressant
vortioxetine enhances cognitive function through a complex mechanism, using serotonergic …

Les bases de pharmacologie fondamentale du système sérotoninergique: application à la réponse antidépressive

DJ David, AM Gardier - L'encéphale, 2016 - Elsevier
Résumé Si la sérotonine ou 5-hydroxytryptamine (5-HT) est peut-être plus connue pour son
rôle dans la régulation de l'humeur, il ne faut pas oublier qu'elle participe à la régulation de …

Response of Htr3a knockout mice to antidepressant treatment and chronic stress

V Martin, A Riffaud, T Marday… - British Journal of …, 2017 - Wiley Online Library
Background and Purpose It has recently been suggested that 5‐HT3 receptor blockade
enhances the efficacy of selective 5‐HT (serotonin) reuptake inhibitor (SSRI) …