Opioids are a mainstay of acute pain management but can have many adverse effects,
contributing to problematic long-term use. Opioid tolerance (increased dose needed for …

Background: The management of acute and chronic pain for individuals living with sickle cell
disease (SCD) is a clinical challenge. This reflects the paucity of clinical SCD pain research …

We summarise the evidence for medicinal uses of opioids, harms related to the extramedical
use of, and dependence on, these drugs, and a wide range of interventions used to address …

Background Chronic pain is common and can be challenging to manage. Despite increased
utilisation of opioids, the safety and efficacy of long‐term use of these compounds for chronic …

Background There is a call for greater monitoring of opioid prescribing in the UK, particularly
of strong opioids in chronic pain, for which there is little evidence of clinical benefit. We …

Introduction From 1986, the World Health Organization (WHO) analgesic ladder has been
used as the simple and valuable pain-relieving guidance in the pharmaceutical pain …

Background Over the last decades, consumption of opioids for the treatment of pain
increased steadily in the United States, Australia, and a few European countries. To date, no …

Background Neuropathic pain, which is caused by a lesion or disease affecting the
somatosensory system, may be central or peripheral in origin. Neuropathic pain often …

Background Acupuncture has been increasingly used in patients with chronic pain, yet no
bibliometric analysis of acupuncture studies for chronic pain exists. Objectives To investigate …

Objective The clinical management of inflammatory pain requires an optimal balance
between effective analgesia and associated safety risks. To date, mechanisms associated …