Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is an incurable
neurodegenerative condition, characterized by the loss of upper and lower motor neurons. It …

Neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, and
amyotrophic lateral sclerosis, are characterized by a progressive loss of selective neuron …

The VAP proteins are integral adaptor proteins of the endoplasmic reticulum (ER)
membrane that recruit a myriad of interacting partners to the ER surface. Through these …

Abstract Phosphatidylinositol 4-kinase (PI4K) is a lipid kinase that can catalyze the transfer
of phosphate group from ATP to the inositol ring of phosphatidylinositol (PtdIns) resulting in …

Nearly twenty years ago a mutation in the VAPB gene, resulting in a proline to serine
substitution (p. P56S), was identified as the cause of a rare, slowly progressing, familial form …

The endoplasmic reticulum (ER) and mitochondria connect at multiple contact sites to form a
unique cellular compartment, termed the 'mitochondria-associated ER membranes'(MAMs) …

Microglia are increasingly recognized as vital players in the pathology of a variety of
neurodegenerative conditions including Alzheimer's (AD) and Parkinson's (PD) disease …

Mitochondria-endoplasmic reticulum contacts (MERCs), also called endoplasmic reticulum
(ER)-mitochondria contact sites (ERMCS), are the membrane domains, where these two …

When considering the vesicle-associated membrane protein-associated protein (VAP)
family, major receptors at the surface of the endoplasmic reticulum (ER), it appears that VAP …

Mitochondria-endoplasmic reticulum contacts (MERCs), also called endoplasmic reticulum
(ER)-mitochondria contact sites (ERMCS), are the membrane domains, where these two …