Serotonin is a key neurotransmitter that is implicated in a wide variety of behavioral and
cognitive phenotypes. Originating in the raphe nuclei, 5-HT neurons project widely to …

Serotonin is a neurotransmitter involved in the modulation of a multitude of physiological
and behavioral processes. In spite of the relatively reduced number of serotonin-producing …

Chronic treatment with fluoxetine (FLX) is required for its antidepressant effects, but the role
of serotonin (5-HT) axonal plasticity in FLX action is unknown. To address this, we examined …

Psychiatric diseases, like depression, largely affect the central nervous system (CNS). While
the underlying neuropathology of depressive illness remains to be elucidated, several …

The self-organization of the brain matrix of serotonergic axons (fibers) remains an unsolved
problem in neuroscience. The regional densities of this matrix have major implications for …

Serotonin-releasing fibers depart from the raphe nuclei to profusely innervate the entire
central nervous system, displaying in some brain regions high structural plasticity in …

Background: Deprivation of extracellular serotonin has been linked to cognitive decline and
neuropsychiatric disturbances in Alzheimer's disease (AD). However, despite degeneration …

The vagus nerve is a major pathway in the body that is responsible for regulating the activity
of the parasympathetic nervous system, which plays an important role in mood disorders …

Vertebrate brains have a dual structure, composed of (i) axons that can be well-captured
with graph-theoretical methods and (ii) axons that form a dense matrix in which neurons with …

Antidepressant fluoxetine (Flx) is the first therapeutic choice for the treatment of major
depression (MD), however neuroanatomical spots of its action remain unclear …