Background Interferon-γ (IFN-γ) plays a key role in activation of cellular immunity and
subsequently, stimulation of antitumor immune-response. Based on its cytostatic, pro …

Several studies have demonstrated that memory T cells including stem cell memory (Tscm)
T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity …

Immune checkpoint inhibitor (ICI) use remains a challenge in patients with solid organ
allografts as most would undergo rejection. In a melanoma patient in whom programmed …

Hypoxia is a common feature in various pathophysiological contexts, including tumor
microenvironment, and IFN-γ is instrumental for anti-tumor immunity. HIF1α has long been …

Background Inclusion body myositis is the most frequent myositis in patients older than 50
years. Classical immunosuppressants are ineffective in treating inclusion body myositis, and …

Alzheimer's Disease (AD) is a progressive neurodegenerative disorder characterized by
extracellular plaques containing abnormal Amyloid Beta (Aβ) aggregates, intracellular …

Epigenetic mechanisms play a critical role during differentiation of T cells by contributing to
the formation of stable and heritable transcriptional patterns. To better understand the …

Human Immunodeficiency Virus (HIV) has plagued human society for a long time since its
discovery, causing a large number of patients to suffer and costing hundreds of millions of …

The treatment and prognosis of advanced colorectal cancer (CRC) remain a challenging
clinical research focus. Here, we describe a new CRC tumor suppressor and potential …

B7-H3 is a type I membrane protein that has contradictory co-stimulatory and co-inhibitory
effects in adaptive and anti-tumour immunity. B7-H3 is up-regulated in many malignant …