Unique biomedical application of fluorescence derivatization based on palladium‐catalyzed coupling reactions for HPLC analysis of pharmaceuticals and …

M El‐Maghrabey, N Kishikawa… - Biomedical …, 2024 - Wiley Online Library
Palladium‐catalyzed coupling reactions are versatile and powerful tools for the construction
of carbon–carbon bonds in organic synthesis. Although these reactions have favorable …

Fluorescence derivatization method for sensitive chromatographic determination of zidovudine based on the Huisgen reaction

Y Maeda, N Kishikawa, K Ohyama, M Wada… - … of Chromatography A, 2014 - Elsevier
A novel pre-column fluorescence derivatization method for chromatographic analysis of
azide compounds was developed based on the Huisgen reaction, which is a specific …

Determination of glyoxylic acid in urine by liquid chromatography with fluorescence detection, using a novel derivatization procedure based on the Petasis reaction

K Chihara, N Kishikawa, K Ohyama… - Analytical and …, 2012 - Springer
The Petasis reaction is the multi-component reaction of a carbonyl compound, amine, and
arylboronic acid to form an α-amino acid or a β-aminoalcohol. In this work, as the first …

The utility of Sonogashira coupling reaction for the derivatization of aryl halides with fluorescent alkyne

N Yasaka, N Kishikawa, T Higashijima, K Ohyama… - Analytical …, 2018 - Springer
Aryl halides are a very important category of compounds that include many vital drugs and
key industrial additives, such as clofibrate and bromobenzene, respectively. Due to their …

Long-wavelength fluorogenic derivatization of aryl halides based on the formation of stilbene by Heck reaction with vinylbenzenes

T Higashijima, N Kishikawa, N Kuroda - Analytical Sciences, 2020 - Springer
The long-wavelength fluorogenic derivatization method for aryl halides was developed
based on stilbene formation by the Heck coupling reaction between aryl halides and …

HPLC determination of chlorpropamide in human serum by fluorogenic derivatization based on the Suzuki coupling reaction with phenylboronic acid

N Kishikawa, SF Hammad, K Ohyama, K Kubo… - Chromatographia, 2013 - Springer
A fluorogenic derivatization method for the determination of chlorpropamide in human serum
was developed by means of high-performance liquid chromatography (HPLC) with …

[PDF][PDF] NAOSITE: Nagasaki University's Academic Output SITE

N Kishikawa, N Kuroda - Journal of Pharmaceutical and Biomedical …, 2014 - core.ac.uk
Simultaneous determination of Hydroxyzine&Cetirizine Page 1 This document is downloaded
at: 2020-09-18T14:04:39Z Title Analytical techniques for the determination of biologically active …

[PDF][PDF] NAOSITE: Nagasaki University's Academic Output SITE

K Chihara, N Kishikawa, K Ohyama… - Analytical and …, 2012 - core.ac.uk
The Petasis reaction is the multi-component reaction of carbonyl compound, amine and
arylboronic acid to form α-amino acid or β-aminoalcohol. In the present work, as a first …

蛍光・化学発光反応に基づく高選択的検出法の開発と生体分析への応用

岸川直哉 - 分析化学, 2012 - jstage.jst.go.jp
抄録 生体内に存在する医薬品やバイオマーカーの濃度を測定することは, 治療効果の確認や疾患
の診断のために重要である. しかしながら, 生体に由来する試料中には 夾 (きょう) …

[引用][C] Suzuki Coupling for the Synthesis of 2-Bromobiphenyl Chromium Tricarbonyl

CC Pollock, CJ Czerwinski