Acute pancreatitis is a common indication for hospital admission, increasing in incidence,
including in children, pregnancy and the elderly. Moderately severe acute pancreatitis with …

The incidence of acute pancreatitis continues to increase worldwide, and it is one of the
most common gastrointestinal causes for hospital admission in the USA. In the past decade …

Chronic pancreatitis is defined as a pathological fibro-inflammatory syndrome of the
pancreas in individuals with genetic, environmental and/or other risk factors who develop …

Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis,
pancreatic genetics has made rapid progress. The identification of mutations in genes …

Background & Aims Pancreatitis starts with primarily sterile local inflammation that induces
systemic inflammatory response syndrome, followed by compensatory anti-inflammatory …

Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known
about its pathogenesis, and there is no specific or effective treatment. Its development …

Background & Aims Acute pancreatitis is characterized by premature intracellular activation
of digestive proteases within pancreatic acini and a consecutive systemic inflammatory …

Animal models of acute and chronic pancreatitis have been created to examine mechanisms
of pathogenesis, test therapeutic interventions, and study the influence of inflammation on …

Inflammation and autophagy are cellular defense mechanisms. When these processes are
deregulated (deficient or overactivated) they produce pathologic effects, such as oxidative …

Oral delivery of small interfering RNA (siRNA) provides a promising paradigm for treating
diseases that require regular injections. However, the multiple gastrointestinal (GI) and …