Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate
vast protein diversity from a limited number of genes. The mechanisms and outcomes of …

RNA-binding proteins (RBPs) are essential for the development and function of the immune
system. They interact dynamically with RNA to control its biogenesis and turnover by …

Abstract Background The World Health Organization characterizes novel coronavirus
disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome …

Over the past decade there has been increased awareness of the potential role of
alternative splicing in the etiology of cancer. In particular, advances in RNA-Sequencing …

Adult stem cells are essential for tissue regeneration. However, the mechanisms underlying
the activation of quiescent adult stem cells remain elusive. Using skeletal muscle stem cells …

MALT1 channels proximal T-cell receptor (TCR) signalling to downstream signalling
pathways. With MALT1A and MALT1B two conserved splice variants exist and we …

Viral infection induces the expression of numerous host genes that impact the outcome of
infection. Here, we show that infection of human lung epithelial cells with influenza A virus …

Intragenic 5‐methylcytosine and CTCF mediate opposing effects on pre‐mRNA splicing:
CTCF promotes inclusion of weak upstream exons through RNA polymerase II pausing …

T cell activation is a well-established model for studying cellular responses to exogenous
stimulation. Using strand-specific RNA-seq, we observed that intron retention is prevalent in …

The mitogen-activated protein kinase (MAPK) cascades transmit signals from extracellular
stimuli to a variety of distinct cellular processes. The MAPKKs in each cascade specifically …